Nucleic acid molecular switches

Garrett A. Soukup; Ronald R. Breaker

doi:10.1016/S0167-7799(99)01383-9

Nucleic acid molecular switches

Garrett A. Soukup, Ronald R. Breaker

Research output: Contribution to journal › Review article › peer-review

123 Scopus citations

Abstract

Natural and artificial ribozymes can catalyse a diverse range of chemical reactions. Through recent efforts in enzyme engineering, it has become possible to tailor the activity of ribozymes to respond allosterically to specific effector compounds. These allosteric ribozymes function as effector-dependent molecular switches that could find application as novel genetic-control elements, biosensor components or precision switches for use in nanotechnology. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	469-476
Number of pages	8
Journal	Trends in Biotechnology
Volume	17
Issue number	12
DOIs	https://doi.org/10.1016/S0167-7799(99)01383-9
State	Published - Dec 1 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering

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10.1016/S0167-7799(99)01383-9

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abstract = "Natural and artificial ribozymes can catalyse a diverse range of chemical reactions. Through recent efforts in enzyme engineering, it has become possible to tailor the activity of ribozymes to respond allosterically to specific effector compounds. These allosteric ribozymes function as effector-dependent molecular switches that could find application as novel genetic-control elements, biosensor components or precision switches for use in nanotechnology. Copyright (C) 1999 Elsevier Science Ltd.",

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AB - Natural and artificial ribozymes can catalyse a diverse range of chemical reactions. Through recent efforts in enzyme engineering, it has become possible to tailor the activity of ribozymes to respond allosterically to specific effector compounds. These allosteric ribozymes function as effector-dependent molecular switches that could find application as novel genetic-control elements, biosensor components or precision switches for use in nanotechnology. Copyright (C) 1999 Elsevier Science Ltd.

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