Nucleic acid molecular switches

Garrett A. Soukup, Ronald R. Breaker

Research output: Contribution to journalReview article

122 Scopus citations


Natural and artificial ribozymes can catalyse a diverse range of chemical reactions. Through recent efforts in enzyme engineering, it has become possible to tailor the activity of ribozymes to respond allosterically to specific effector compounds. These allosteric ribozymes function as effector-dependent molecular switches that could find application as novel genetic-control elements, biosensor components or precision switches for use in nanotechnology. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)469-476
Number of pages8
JournalTrends in Biotechnology
Issue number12
StatePublished - Dec 1 1999


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

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