Occult left ventricular dysfunction diagnosed by myocardial performance index in patients with limb girdle muscle dystrophy: A case control study

Rajashekar R. Gurrala, Venkata M.B. Alla, Wilbert S. Aronow, Jai S. Shankar, Meena K. Angamutta, Krishna S.R. Lanka, Sundaram Challa, Chandra K. Nair

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The myocardial performance index (MPI) was assessed in 30 patients with limb girdle muscle dystrophy (LGMD) with a normal left ventricular ejection fraction (greater than 50%), as well as in 30 age-and sex-matched healthy adults with a left ventricular ejection fraction greater than 50%. MPIs derived by pulsed-wave Doppler and tissue Doppler were also compared. The MPI was 0.37±0.09 in the LGMD patients and 0.29±0.09 in the control group (P=0.003). These data show that patients with LGMD have occult cardiac dysfunction as evidenced by a higher MPI than the controls. There was good agreement between the MPIs measured by pulsed-wave Doppler and tissue Doppler methods in these patients.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalInternational Journal of Angiology
Issue number4
StatePublished - Sep 1 2007


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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