Oestrogen receptor status and survival in women with BRCA2-associated breast cancer

Kelly Metcalfe, Henry T. Lynch, William D. Foulkes, Nadine Tung, Olufunmilayo I. Olopade, Andrea Eisen, Jordan Lerner-Ellis, Carrie Snyder, Shana J. Kim, Ping Sun, Steven A. Narod

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Abstract

Background: To evaluate the predictors of mortality, including ER status, in women with a BRCA2 mutation and breast cancer. Methods: Eligible participants were identified from within two longitudinal cohorts. These patients were selected because they were diagnosed with breast cancer between 1975 and 2015 and carried a BRCA2 mutation. Data were abstracted from the medical record and pathology report. We analysed the effects of ER status and other variables on breast cancer specific survival using a Cox proportional hazards model. Results: Three hundred ninety women with breast cancer and a BRCA2 mutation were included in the analysis. The mean follow-up time was 12.3 years (range 1–39 years) and 89 subjects died (22.8%). In the multivariate analysis, women with ER-positive tumours were more likely to die than women with ER-negative tumours (HR 2.08, 95% CI 0.99–4.36, p = 0.05), and this was of borderline significance. For the 233 women with ER-positive tumours the 20-year survival rate was 62.2%, compared to 83.7% for 58 women with ER-negative tumours (p = 0.03). Conclusions: The majority of women with a BRCA2 mutation present with ER-positive breast cancer, and for these women, prognosis may be worse than for BRCA2 carriers with ER-negative breast cancer.

Original languageEnglish (US)
JournalBritish Journal of Cancer
DOIs
StatePublished - Jan 1 2019

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Metcalfe, K., Lynch, H. T., Foulkes, W. D., Tung, N., Olopade, O. I., Eisen, A., Lerner-Ellis, J., Snyder, C., Kim, S. J., Sun, P., & Narod, S. A. (2019). Oestrogen receptor status and survival in women with BRCA2-associated breast cancer. British Journal of Cancer. https://doi.org/10.1038/s41416-019-0376-y