Oligodendrocyte-type 2 astrocyte-derived trophic factors increase survival of developing dopamine neurons through the inhibition of apoptotic cell death

Deniz M. Yilmazer-Hanke, Robyn Hudson, Hans Distel

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Survival of embryonic dopamine (DA) neurons is extremely low (5-20%) following transplantation. Strategies to increase this survival are critical to the future of transplantation for Parkinson's disease. We demonstrate here that a factor(s) released from striatal oligodendrocyte-type 2 astrocytes (SO2A) greatly improves the survival and phenotype expression of mesencephalic DA neurons in culture while simultaneously decreasing the presence of apoptotic nuclear profiles, as detected by the TUNEL method and bisbenzamide/tyrosine hydroxylase double labeling. This SO2A-derived trophic factor(s) has minimal effects on glia and no effect on nondopaminergic mesencephalic neurons. The developmental period during which this SO2A trophic effect occurs (E14-18) coincides with the period when mesencephalic grafts are undergoing the highest rates of apoptosis, i.e., immediately following implantation. Therefore, SO2A-derived trophic factor(s) offers great potential for the augmentation of grafted DA neuron survival. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)143-153
Number of pages11
JournalJournal of Comparative Neurology
Volume426
Issue number1
DOIs
StatePublished - Oct 9 2000
Externally publishedYes

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Corpus Striatum
Dopaminergic Neurons
Oligodendroglia
Astrocytes
Cell Death
Transplantation
In Situ Nick-End Labeling
Tyrosine 3-Monooxygenase
Neuroglia
Parkinson Disease
Apoptosis
Transplants
Phenotype
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Oligodendrocyte-type 2 astrocyte-derived trophic factors increase survival of developing dopamine neurons through the inhibition of apoptotic cell death. / Yilmazer-Hanke, Deniz M.; Hudson, Robyn; Distel, Hans.

In: Journal of Comparative Neurology, Vol. 426, No. 1, 09.10.2000, p. 143-153.

Research output: Contribution to journalArticle

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AB - Survival of embryonic dopamine (DA) neurons is extremely low (5-20%) following transplantation. Strategies to increase this survival are critical to the future of transplantation for Parkinson's disease. We demonstrate here that a factor(s) released from striatal oligodendrocyte-type 2 astrocytes (SO2A) greatly improves the survival and phenotype expression of mesencephalic DA neurons in culture while simultaneously decreasing the presence of apoptotic nuclear profiles, as detected by the TUNEL method and bisbenzamide/tyrosine hydroxylase double labeling. This SO2A-derived trophic factor(s) has minimal effects on glia and no effect on nondopaminergic mesencephalic neurons. The developmental period during which this SO2A trophic effect occurs (E14-18) coincides with the period when mesencephalic grafts are undergoing the highest rates of apoptosis, i.e., immediately following implantation. Therefore, SO2A-derived trophic factor(s) offers great potential for the augmentation of grafted DA neuron survival. (C) 2000 Wiley-Liss, Inc.

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