Omalizumab for pediatric asthma

Robert G. Townley, Swati Agrawal, Kiran Sapkota

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Importance to the field: Omalizumab is of proven efficacy in the treatment of severe allergic bronchial asthma and works through inhibiting the activity of IgE and the allergic immune mechanism IgE mediates. It has been demonstrated to be efficacious in children with asthma but is not approved by the FDA for use in children below 12 years of age. Areas covered in this review: Omalizumab is a 95% humanized monoclonal antibody that binds to circulating IgE at the same site on the Fc domain as the high-affinity IgE receptor, FcεRI. This blocks the interaction between IgE and mast cells and basophils, thereby preventing the release of inflammatory mediators that cause allergic signs and symptoms. What the reader will gain: From the review of the literatures and statements from the FDA, Genentec and Novartis, the reader will gain a better appreciation of the value of omalizumab in treatment of severe asthma and the current status of its reported side effects. Take home message: Omalizumab is of proven efficacy in adults and children with severe asthma and allows a markedly reduced dependence on oral and inhaled corticosteroids and decreased hospitalizations. A potential mechanism of omalizumab's effect on thrombus formation and cardiovascular effect is postulated.

Original languageEnglish (US)
Pages (from-to)1595-1608
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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    Townley, R. G., Agrawal, S., & Sapkota, K. (2010). Omalizumab for pediatric asthma. Expert Opinion on Biological Therapy, 10(11), 1595-1608. https://doi.org/10.1517/14712598.2010.526103