Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption

Donald W. Miller, Samuel C. Augustine, Dennis H. Robinson, Jonathan L. Vennerstrom, Jon C. Wagner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.

Original languageEnglish
Title of host publicationNutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength
PublisherElsevier Inc.
Pages395-403
Number of pages9
ISBN (Print)9780123964540
DOIs
StatePublished - Aug 2013

Fingerprint

creatine
Creatine
Biological Availability
bioavailability
mouth
Muscle
muscle strength
Muscle Strength
gastrointestinal system
Intestines
Gastrointestinal Tract
intestines
Muscles
muscles

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Miller, D. W., Augustine, S. C., Robinson, D. H., Vennerstrom, J. L., & Wagner, J. C. (2013). Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption. In Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength (pp. 395-403). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-396454-0.00040-0

Oral Bioavailability of Creatine Supplements : Insights into Mechanism and Implications for Improved Absorption. / Miller, Donald W.; Augustine, Samuel C.; Robinson, Dennis H.; Vennerstrom, Jonathan L.; Wagner, Jon C.

Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. Elsevier Inc., 2013. p. 395-403.

Research output: Chapter in Book/Report/Conference proceedingChapter

Miller, DW, Augustine, SC, Robinson, DH, Vennerstrom, JL & Wagner, JC 2013, Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption. in Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. Elsevier Inc., pp. 395-403. https://doi.org/10.1016/B978-0-12-396454-0.00040-0
Miller DW, Augustine SC, Robinson DH, Vennerstrom JL, Wagner JC. Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption. In Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. Elsevier Inc. 2013. p. 395-403 https://doi.org/10.1016/B978-0-12-396454-0.00040-0
Miller, Donald W. ; Augustine, Samuel C. ; Robinson, Dennis H. ; Vennerstrom, Jonathan L. ; Wagner, Jon C. / Oral Bioavailability of Creatine Supplements : Insights into Mechanism and Implications for Improved Absorption. Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength. Elsevier Inc., 2013. pp. 395-403
@inbook{50e61132d5594e56a3318c7e4ddcdec9,
title = "Oral Bioavailability of Creatine Supplements: Insights into Mechanism and Implications for Improved Absorption",
abstract = "Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.",
author = "Miller, {Donald W.} and Augustine, {Samuel C.} and Robinson, {Dennis H.} and Vennerstrom, {Jonathan L.} and Wagner, {Jon C.}",
year = "2013",
month = "8",
doi = "10.1016/B978-0-12-396454-0.00040-0",
language = "English",
isbn = "9780123964540",
pages = "395--403",
booktitle = "Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength",
publisher = "Elsevier Inc.",
address = "United States",

}

TY - CHAP

T1 - Oral Bioavailability of Creatine Supplements

T2 - Insights into Mechanism and Implications for Improved Absorption

AU - Miller, Donald W.

AU - Augustine, Samuel C.

AU - Robinson, Dennis H.

AU - Vennerstrom, Jonathan L.

AU - Wagner, Jon C.

PY - 2013/8

Y1 - 2013/8

N2 - Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.

AB - Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of reasons to suggest creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and the implications for improving the bioavailability of creatine supplements.

UR - http://www.scopus.com/inward/record.url?scp=84902559914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902559914&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-396454-0.00040-0

DO - 10.1016/B978-0-12-396454-0.00040-0

M3 - Chapter

AN - SCOPUS:84902559914

SN - 9780123964540

SP - 395

EP - 403

BT - Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength

PB - Elsevier Inc.

ER -