Oral Bioavailability of Creatine Supplements: Insights Into Mechanism and Implications for Improved Absorption

Eman A. Alraddadi, Samuel Augustine, Dennis H. Robinson, Jonathan L. Vennerstrom, Jon C. Wagner, Donald W. Miller

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of findings that suggest that creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and implications for improving the bioavailability of creatine supplements.

Original languageEnglish (US)
Title of host publicationNutrition and Enhanced Sports Performance
Subtitle of host publicationMuscle Building, Endurance, and Strength
PublisherElsevier
Pages595-604
Number of pages10
ISBN (Print)9780128139226
DOIs
StatePublished - Oct 10 2018

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Agricultural and Biological Sciences(all)

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    Alraddadi, E. A., Augustine, S., Robinson, D. H., Vennerstrom, J. L., Wagner, J. C., & Miller, D. W. (2018). Oral Bioavailability of Creatine Supplements: Insights Into Mechanism and Implications for Improved Absorption. In Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength (pp. 595-604). Elsevier. https://doi.org/10.1016/B978-0-12-813922-6.00050-3