Orbital Spaceflight During Pregnancy Shapes Function of Mammalian Vestibular System

April E. Ronca, Bernd Fritzsch, Laura Bruce, Jeffrey R. Alberts

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Pregnant rats were flown on the NASA Space Shuttle during the early developmental period of their fetuses' vestibular apparatus and onset of vestibular function. The authors report that prenatal spaceflight exposure shapes vestibular-mediated behavior and central morphology. Postflight testing revealed (a) delayed onset of body righting responses, (b) cardiac deceleration (bradycardia) to 70 o head-up roll, (c) decreased branching of gravistatic afferent axons, but (d) no change in branching of angular acceleration receptor projections with comparable synaptogenesis of the medial vestibular nucleus in flight relative to control fetuses. Kinematic analyses of the dams' on-orbit behavior suggest that, although the fetal otolith organs are unloaded in microgravity, the fetus' semicircular canals receive high levels of stimulation during longitudinal rotations of the mother's weightless body. Behaviorally derived stimulation from maternal movements may be a significant factor in studies of vestibular sensory development. Taken together, these studies provide evidence that gravity and angular acceleration shape prenatal organization and function within the mammalian vestibular system.

Original languageEnglish
Pages (from-to)224-232
Number of pages9
JournalBehavioral Neuroscience
Volume122
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

Space Flight
Fetus
Pregnancy
Labyrinth Vestibule
United States National Aeronautics and Space Administration
Righting Reflex
Otolithic Membrane
Vestibular Nuclei
Semicircular Canals
Weightlessness
Deceleration
Gravitation
Orbit
Bradycardia
Biomechanical Phenomena
Axons
Head
Mothers
Organizations

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Orbital Spaceflight During Pregnancy Shapes Function of Mammalian Vestibular System. / Ronca, April E.; Fritzsch, Bernd; Bruce, Laura; Alberts, Jeffrey R.

In: Behavioral Neuroscience, Vol. 122, No. 1, 02.2008, p. 224-232.

Research output: Contribution to journalArticle

Ronca, April E. ; Fritzsch, Bernd ; Bruce, Laura ; Alberts, Jeffrey R. / Orbital Spaceflight During Pregnancy Shapes Function of Mammalian Vestibular System. In: Behavioral Neuroscience. 2008 ; Vol. 122, No. 1. pp. 224-232.
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