Organ of corti and stria vascularis: Is there an interdependence for survival?

Huizhan Liu, Yi Li, Lei Chen, Qian Zhang, Ning Pan, David H. Nichols, Weiping J. Zhang, Bernd Fritzsch, David Z. He

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cochlear hair cells and the stria vascularis are critical for normal hearing. Hair cells transduce mechanical stimuli into electrical signals, whereas the stria is responsible for generating the endocochlear potential (EP), which is the driving force for hair cell mechanotransduction. We questioned whether hair cells and the stria interdepend for survival by using two mouse models. Atoh1 conditional knockout mice, which lose all hair cells within four weeks after birth, were used to determine whether the absence of hair cells would affect function and survival of stria. We showed that stria morphology and EP remained normal for long time despite a complete loss of all hair cells. We then used a mouse model that has an abnormal stria morphology and function due to mutation of the Mitf gene to determine whether hair cells are able to survive and transduce sound signals without a normal electrochemical environment in the endolymph. A strial defect, reflected by missing intermediate cells in the stria and by reduction of EP, led to systematic outer hair cell death from the base to the apex after postnatal day 18. However, an 18-mV EP was sufficient for outer hair cell survival. Surprisingly, inner hair cell survival was less vulnerable to reduction of the EP. Our studies show that normal function of the stria is essential for adult outer hair cell survival, while the survival and normal function of the stria vascularis do not depend on functional hair cells.

Original languageEnglish (US)
Article numbere0168953
JournalPLoS One
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2016

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Stria Vascularis
Organ of Corti
hairs
Cells
Outer Auditory Hair Cells
Cell Survival
cells
Inner Auditory Hair Cells
cell viability
Auditory Hair Cells
Endolymph
Alopecia
animal models
Knockout Mice
Hearing
Audition
Cell Death
Cell death
hearing
Parturition

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Organ of corti and stria vascularis : Is there an interdependence for survival? / Liu, Huizhan; Li, Yi; Chen, Lei; Zhang, Qian; Pan, Ning; Nichols, David H.; Zhang, Weiping J.; Fritzsch, Bernd; He, David Z.

In: PLoS One, Vol. 11, No. 12, e0168953, 01.12.2016.

Research output: Contribution to journalArticle

Liu, H, Li, Y, Chen, L, Zhang, Q, Pan, N, Nichols, DH, Zhang, WJ, Fritzsch, B & He, DZ 2016, 'Organ of corti and stria vascularis: Is there an interdependence for survival?', PLoS One, vol. 11, no. 12, e0168953. https://doi.org/10.1371/journal.pone.0168953
Liu H, Li Y, Chen L, Zhang Q, Pan N, Nichols DH et al. Organ of corti and stria vascularis: Is there an interdependence for survival? PLoS One. 2016 Dec 1;11(12). e0168953. https://doi.org/10.1371/journal.pone.0168953
Liu, Huizhan ; Li, Yi ; Chen, Lei ; Zhang, Qian ; Pan, Ning ; Nichols, David H. ; Zhang, Weiping J. ; Fritzsch, Bernd ; He, David Z. / Organ of corti and stria vascularis : Is there an interdependence for survival?. In: PLoS One. 2016 ; Vol. 11, No. 12.
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