Osteoporotic Bone Fragility

Detection by Ultrasound Transmission Velocity

Robert P. Heaney, Louis V. Avioli, Charles H. Chesnut, Joan M. Lappe, Robert R. Recker, Gary H. Brandenburger

Research output: Contribution to journalArticle

219 Citations (Scopus)

Abstract

We evaluated ultrasound transmission velocity at the patella as an indicator of osteoporotic fragility in 293 nonobese women. Osteoporosis was defined by atraumatic vertebral compression deformity. Ultrasound velocity averaged 1954 ±71 (±SD) m/s in premenopausal normal women and declined significantly with age after menopause, largely independently of age-related loss of spine bone mass. Postmenopausal osteoporotic women had lower velocities than normal women (-76 m/s). After allowing for slight differences in age between the groups, the difference ( - 54 m/s) was still significant. Women with velocities below 1825 m/s were about six times more likely to have one or more fractures than women with velocities above that level. By sensitivity-specificity analysis, ultrasound velocity discriminated between normal and osteoporotic women as well as direct measurement of spine bone mass. Ultrasound velocity measures both bone mass and a component of bone fragility distinct from decreased mass; it is a potentially valuable new tool for evaluating women for osteoporotic fragility.

Original languageEnglish
Pages (from-to)2986-2990
Number of pages5
JournalJAMA - Journal of the American Medical Association
Volume261
Issue number20
DOIs
StatePublished - May 26 1989

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Bone and Bones
Osteoporosis
Spine
Patella
Menopause
Age Groups
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Osteoporotic Bone Fragility : Detection by Ultrasound Transmission Velocity. / Heaney, Robert P.; Avioli, Louis V.; Chesnut, Charles H.; Lappe, Joan M.; Recker, Robert R.; Brandenburger, Gary H.

In: JAMA - Journal of the American Medical Association, Vol. 261, No. 20, 26.05.1989, p. 2986-2990.

Research output: Contribution to journalArticle

Heaney, Robert P. ; Avioli, Louis V. ; Chesnut, Charles H. ; Lappe, Joan M. ; Recker, Robert R. ; Brandenburger, Gary H. / Osteoporotic Bone Fragility : Detection by Ultrasound Transmission Velocity. In: JAMA - Journal of the American Medical Association. 1989 ; Vol. 261, No. 20. pp. 2986-2990.
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