Over-the-scope clip as first-line therapy for ulcers with high-risk bleeding stigmata is efficient compared to standard endoscopic therapy

Avanija Buddam, Sirish Rao, Jahnavi Koppala, Rajani Rangray, Abdullah Abdussalam, Sandeep Mukherjee, Subhash Chandra

Research output: Contribution to journalArticlepeer-review


Background and study aims Ulcers with high-risk stigmata have significant rebleeding rates despite standard endoscopic therapy. Data on over-the-scope clip (OTSC) for recurrent bleeding is promising but data on first line therapy is lacking. We report comparative outcomes of OTSC as first-line therapy versus standard endoscopic therapy in ulcers with high-risk stigmata. Patients and methods Consecutive adults who underwent endoscopic therapy for ulcers with high-risk stigmata between July 2019 to September 2020 were included. Patients were grouped into OTSC or standard therapy based on first-line therapy used on index endoscopy. Outcomes measured included: 1) intra-procedural hemostasis based on endoscopic documentation of adequate hemostasis; 2) 7-day rebleeding (>2g/dL drop in hemoglobin, hematochezia or hemorrhagic shock); 3) cost of endoscopic interventions; and 4) procedure duration measured as endoscope insertion to removal time. Cost of tools used during the index endoscopy was included. Results Sixty-eight patients were included, 47 were in standard therapy and 21 in the OTSC group. Hemostasis was achieved in 95.2% in the OTSC group compared to 83.0% in the standard therapy group (P =0.256, number needed to treat [NNT]: 9). Procedure time was shorter in the OTSC group (23 vs. 16 minutes, P =0.002). Cost of endoscopic interventions were comparable, P =0.203. Early rebleeding was less often in OTSC group, two (9.5%) compared to 10 (21.3%) in standard therapy group, NNT 9. Conclusions Use of OTSCs as first-line treatment for ulcers bleed probably improves hemostasis and decreases early rebleeding. Use of OTSC as first-line therapy shortened procedure duration without increasing the cost of endoscopic interventions.

Original languageEnglish (US)
Pages (from-to)E1530-E1535
JournalEndoscopy International Open
Issue number10
StatePublished - Oct 1 2021

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Gastroenterology


Dive into the research topics of 'Over-the-scope clip as first-line therapy for ulcers with high-risk bleeding stigmata is efficient compared to standard endoscopic therapy'. Together they form a unique fingerprint.

Cite this