TY - JOUR
T1 - Oxygen regulates molecular mechanisms of cancer progression and metastasis
AU - Gupta, Kartik
AU - Madan, Esha
AU - Sayyid, Muzzammil
AU - Arias-Pulido, Hugo
AU - Moreno, Eduardo
AU - Kuppusamy, Periannan
AU - Gogna, Rajan
N1 - Funding Information:
Acknowledgments The manuscript is supported by Swiss Cancer league research grant to Rajan Gogna and Eduardo Moreno.
PY - 2014/3
Y1 - 2014/3
N2 - Oxygen is the basic molecule which supports life and it truly is "god's gift to life." Despite its immense importance, research on "oxygen biology" has never received the light of the day and has been limited to physiological and biochemical studies. It seems that in modern day biology, oxygen research is summarized in one word "hypoxia." Scientists have focused on hypoxia-induced transcriptomics and molecular-cellular alterations exclusively in disease models. Interestingly, the potential of oxygen to control the basic principles of biology like homeostatic maintenance, transcription, replication, and protein folding among many others, at the molecular level, has been completely ignored. Here, we present a perspective on the crucial role played by oxygen in regulation of basic biological phenomena. Our conclusion highlights the importance of establishing novel research areas like oxygen biology, as there is great potential in this field for basic science discoveries and clinical benefits to the society.
AB - Oxygen is the basic molecule which supports life and it truly is "god's gift to life." Despite its immense importance, research on "oxygen biology" has never received the light of the day and has been limited to physiological and biochemical studies. It seems that in modern day biology, oxygen research is summarized in one word "hypoxia." Scientists have focused on hypoxia-induced transcriptomics and molecular-cellular alterations exclusively in disease models. Interestingly, the potential of oxygen to control the basic principles of biology like homeostatic maintenance, transcription, replication, and protein folding among many others, at the molecular level, has been completely ignored. Here, we present a perspective on the crucial role played by oxygen in regulation of basic biological phenomena. Our conclusion highlights the importance of establishing novel research areas like oxygen biology, as there is great potential in this field for basic science discoveries and clinical benefits to the society.
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U2 - 10.1007/s10555-013-9464-2
DO - 10.1007/s10555-013-9464-2
M3 - Review article
C2 - 24338006
AN - SCOPUS:84899981288
VL - 33
SP - 183
EP - 215
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
SN - 0167-7659
IS - 1
ER -