Palmyrolide A, an unusually stabilized neuroactive macrolide from palmyra atoll cyanobacteria

Alban R. Pereira, Zhengyu Cao, Niclas Engene, Irma E. Soria-Mercado, Thomas F. Murray, William H. Gerwick

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Palmyrolide A (1) is a new neuroactive macrolide isolated from a marine cyanobacterial assemblage composed of Leptolyngbya cf. and Oscillatoria spp. collected from Palmyra Atoll. It features a rare N-methyl enamide and an intriguing t-butyl branch; the latter renders the adjacent lactone ester bond resistant to hydrolysis. Consistent with its significant suppression of calcium influx in cerebrocortical neurons (IC50 = 3.70 μM), palmyrolide A (1) showed a relatively potent sodium channel blocking activity in neuro-2a cells (IC50 = 5.2 μM), without appreciable cytotoxicity.

Original languageEnglish (US)
Pages (from-to)4490-4493
Number of pages4
JournalOrganic Letters
Issue number20
StatePublished - Oct 15 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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