Abstract
Palmyrolide A (1) is a new neuroactive macrolide isolated from a marine cyanobacterial assemblage composed of Leptolyngbya cf. and Oscillatoria spp. collected from Palmyra Atoll. It features a rare N-methyl enamide and an intriguing t-butyl branch; the latter renders the adjacent lactone ester bond resistant to hydrolysis. Consistent with its significant suppression of calcium influx in cerebrocortical neurons (IC50 = 3.70 μM), palmyrolide A (1) showed a relatively potent sodium channel blocking activity in neuro-2a cells (IC50 = 5.2 μM), without appreciable cytotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 4490-4493 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 12 |
| Issue number | 20 |
| DOIs | |
| State | Published - Oct 15 2010 |
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All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
Cite this
Palmyrolide A, an unusually stabilized neuroactive macrolide from palmyra atoll cyanobacteria. / Pereira, Alban R.; Cao, Zhengyu; Engene, Niclas; Soria-Mercado, Irma E.; Murray, Thomas F.; Gerwick, William H.
In: Organic Letters, Vol. 12, No. 20, 15.10.2010, p. 4490-4493.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Palmyrolide A, an unusually stabilized neuroactive macrolide from palmyra atoll cyanobacteria
AU - Pereira, Alban R.
AU - Cao, Zhengyu
AU - Engene, Niclas
AU - Soria-Mercado, Irma E.
AU - Murray, Thomas F.
AU - Gerwick, William H.
PY - 2010/10/15
Y1 - 2010/10/15
N2 - Palmyrolide A (1) is a new neuroactive macrolide isolated from a marine cyanobacterial assemblage composed of Leptolyngbya cf. and Oscillatoria spp. collected from Palmyra Atoll. It features a rare N-methyl enamide and an intriguing t-butyl branch; the latter renders the adjacent lactone ester bond resistant to hydrolysis. Consistent with its significant suppression of calcium influx in cerebrocortical neurons (IC50 = 3.70 μM), palmyrolide A (1) showed a relatively potent sodium channel blocking activity in neuro-2a cells (IC50 = 5.2 μM), without appreciable cytotoxicity.
AB - Palmyrolide A (1) is a new neuroactive macrolide isolated from a marine cyanobacterial assemblage composed of Leptolyngbya cf. and Oscillatoria spp. collected from Palmyra Atoll. It features a rare N-methyl enamide and an intriguing t-butyl branch; the latter renders the adjacent lactone ester bond resistant to hydrolysis. Consistent with its significant suppression of calcium influx in cerebrocortical neurons (IC50 = 3.70 μM), palmyrolide A (1) showed a relatively potent sodium channel blocking activity in neuro-2a cells (IC50 = 5.2 μM), without appreciable cytotoxicity.
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U2 - 10.1021/ol101752n
DO - 10.1021/ol101752n
M3 - Article
VL - 12
SP - 4490
EP - 4493
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 20
ER -