Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome

Henry T. Lynch, Ramon M. Fusaro

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

The role of host factors in the etiology of pancreatic cancer has received a paucity of systematic investigation. Anecdotal reports and one population-based study have supported the concept that familial clustering of this disease exists. We have studied a kindred with a cancer-associated genodermatosis known as familial atypical multiple mole melanoma (FAMMM) syndrome (hereditary dysplastic nevus syndrome). Three key relatives have manifested pancreatic carcinoma. Since FAMMM may account for as much as 10% of the total malignant melanoma burden, its association with pancreatic cancer harbors important public health implications. Given the fact that the etiology of pancreatic cancer remains enigmatic, it is important to investigate all possible clues to its causality, including the potential role of host factors.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalPancreas
Volume6
Issue number2
DOIs
StatePublished - Mar 1991

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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