Parasite-directed endocytosis.

Z. A. McGee, Gary L. Gorby, P. B. Wyrick, R. Hodinka, L. H. Hoffman

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Following the attachment of gonococci to human fallopian tube mucosa in organ culture, the gonococci are endocytosed by specialized low columnar epithelial cells, are transported to the base of the epithelial cells, and are subsequently exocytosed into the subepithelial tissues. This transepithelial transport process by which "invasion" of the host occurs appears to be dependent on microbial factors is designated parasite-directed endocytosis to distinguish it from host-directed endocytosis by cells such as macrophages that eventually degrade the parasites. "Invasion" of the host by a number of human pathogens--bacteria (e.g., Neisseria meningitidis, Haemophilus influenzae, and Listeria monocytogenes), viruses, or protozoa--appears to be accomplished by parasite-directed endocytosis.

Original languageEnglish
JournalReviews of Infectious Diseases
Volume10 Suppl 2
StatePublished - Jul 1988
Externally publishedYes

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Endocytosis
Parasites
Neisseria gonorrhoeae
Epithelial Cells
Neisseria meningitidis
Fallopian Tubes
Organ Culture Techniques
Haemophilus influenzae
Listeria monocytogenes
Mucous Membrane
Macrophages
Viruses
Bacteria

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

McGee, Z. A., Gorby, G. L., Wyrick, P. B., Hodinka, R., & Hoffman, L. H. (1988). Parasite-directed endocytosis. Reviews of Infectious Diseases, 10 Suppl 2.

Parasite-directed endocytosis. / McGee, Z. A.; Gorby, Gary L.; Wyrick, P. B.; Hodinka, R.; Hoffman, L. H.

In: Reviews of Infectious Diseases, Vol. 10 Suppl 2, 07.1988.

Research output: Contribution to journalReview article

McGee, ZA, Gorby, GL, Wyrick, PB, Hodinka, R & Hoffman, LH 1988, 'Parasite-directed endocytosis.', Reviews of Infectious Diseases, vol. 10 Suppl 2.
McGee ZA, Gorby GL, Wyrick PB, Hodinka R, Hoffman LH. Parasite-directed endocytosis. Reviews of Infectious Diseases. 1988 Jul;10 Suppl 2.
McGee, Z. A. ; Gorby, Gary L. ; Wyrick, P. B. ; Hodinka, R. ; Hoffman, L. H. / Parasite-directed endocytosis. In: Reviews of Infectious Diseases. 1988 ; Vol. 10 Suppl 2.
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