Abstract
Following the attachment of gonococci to human fallopian tube mucosa in organ culture, the gonococci are endocytosed by specialized low columnar epithelial cells, are transported to the base of the epithelial cells, and are subsequently exocytosed into the subepithelial tissues. This transepithelial transport process by which "invasion" of the host occurs appears to be dependent on microbial factors is designated parasite-directed endocytosis to distinguish it from host-directed endocytosis by cells such as macrophages that eventually degrade the parasites. "Invasion" of the host by a number of human pathogens--bacteria (e.g., Neisseria meningitidis, Haemophilus influenzae, and Listeria monocytogenes), viruses, or protozoa--appears to be accomplished by parasite-directed endocytosis.
| Original language | English |
|---|---|
| Journal | Reviews of Infectious Diseases |
| Volume | 10 Suppl 2 |
| State | Published - Jul 1988 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Microbiology (medical)
Cite this
Parasite-directed endocytosis. / McGee, Z. A.; Gorby, Gary L.; Wyrick, P. B.; Hodinka, R.; Hoffman, L. H.
In: Reviews of Infectious Diseases, Vol. 10 Suppl 2, 07.1988.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Parasite-directed endocytosis.
AU - McGee, Z. A.
AU - Gorby, Gary L.
AU - Wyrick, P. B.
AU - Hodinka, R.
AU - Hoffman, L. H.
PY - 1988/7
Y1 - 1988/7
N2 - Following the attachment of gonococci to human fallopian tube mucosa in organ culture, the gonococci are endocytosed by specialized low columnar epithelial cells, are transported to the base of the epithelial cells, and are subsequently exocytosed into the subepithelial tissues. This transepithelial transport process by which "invasion" of the host occurs appears to be dependent on microbial factors is designated parasite-directed endocytosis to distinguish it from host-directed endocytosis by cells such as macrophages that eventually degrade the parasites. "Invasion" of the host by a number of human pathogens--bacteria (e.g., Neisseria meningitidis, Haemophilus influenzae, and Listeria monocytogenes), viruses, or protozoa--appears to be accomplished by parasite-directed endocytosis.
AB - Following the attachment of gonococci to human fallopian tube mucosa in organ culture, the gonococci are endocytosed by specialized low columnar epithelial cells, are transported to the base of the epithelial cells, and are subsequently exocytosed into the subepithelial tissues. This transepithelial transport process by which "invasion" of the host occurs appears to be dependent on microbial factors is designated parasite-directed endocytosis to distinguish it from host-directed endocytosis by cells such as macrophages that eventually degrade the parasites. "Invasion" of the host by a number of human pathogens--bacteria (e.g., Neisseria meningitidis, Haemophilus influenzae, and Listeria monocytogenes), viruses, or protozoa--appears to be accomplished by parasite-directed endocytosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024044795&partnerID=8YFLogxK
M3 - Review article
C2 - 3142016
AN - SCOPUS:0024044795
VL - 10 Suppl 2
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
ER -