Paravertebral malignant rhabdoid tumor in infancy. In vitro studies of a familial tumor

Henry T. Lynch, S. B. Shurin, B. B. Dahms, R. J. Izant, J. Lynch, B. S. Danes

Research output: Contribution to journalArticle

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Abstract

Two female siblings died within three months after presenting with paravertebral tumors in the first year of life. The pathology of the two tumors was identical and characteristic of a malignant rhabdoid tumor. There were no identifiable tumor patterns within the kindred which have been associated with any hereditary cancer or precancer syndromes. Fibroblasts were cultured from skin biopsies obtained from the second patient and both parents. Assays of growth kinetics associated with cellular transformation revealed that fibroblasts from the affected sibling can be distinguished from those of the parents and age-matched controls by increased in vitro occurrence of tetraploidy. Such evidence suggests that increased in vitro tetraploidy occurring spontaneously in cultured fibroblasts is an expression of a cancer-prone gene. Increased in vitro tetraploidy has previously been demonstrated in some kindreds with heritable colon cancer syndromes, and may extend our understanding of the genetic etiology of some childhood cancers.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalCancer
Volume52
Issue number2
StatePublished - 1983

Fingerprint

Rhabdoid Tumor
Tetraploidy
Fibroblasts
Neoplasms
Siblings
Parents
Neoplasm Genes
Colonic Neoplasms
In Vitro Techniques
Pathology
Biopsy
Skin
Growth

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Shurin, S. B., Dahms, B. B., Izant, R. J., Lynch, J., & Danes, B. S. (1983). Paravertebral malignant rhabdoid tumor in infancy. In vitro studies of a familial tumor. Cancer, 52(2), 290-296.

Paravertebral malignant rhabdoid tumor in infancy. In vitro studies of a familial tumor. / Lynch, Henry T.; Shurin, S. B.; Dahms, B. B.; Izant, R. J.; Lynch, J.; Danes, B. S.

In: Cancer, Vol. 52, No. 2, 1983, p. 290-296.

Research output: Contribution to journalArticle

Lynch, HT, Shurin, SB, Dahms, BB, Izant, RJ, Lynch, J & Danes, BS 1983, 'Paravertebral malignant rhabdoid tumor in infancy. In vitro studies of a familial tumor', Cancer, vol. 52, no. 2, pp. 290-296.
Lynch HT, Shurin SB, Dahms BB, Izant RJ, Lynch J, Danes BS. Paravertebral malignant rhabdoid tumor in infancy. In vitro studies of a familial tumor. Cancer. 1983;52(2):290-296.
Lynch, Henry T. ; Shurin, S. B. ; Dahms, B. B. ; Izant, R. J. ; Lynch, J. ; Danes, B. S. / Paravertebral malignant rhabdoid tumor in infancy. In vitro studies of a familial tumor. In: Cancer. 1983 ; Vol. 52, No. 2. pp. 290-296.
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