Patent Ductus Arteriosus

Study of two Families

Henry T. Lynch, R. L. Grissom, C. R. Magnuson, A. Krush

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Patent ductus arteriosus (PDA) has been found in several members in consecutive generations of two families. In one family the proband's father had affected children through two matings with unrelated wives. In both families, operation confirmed the PDA in each case in two generations. However, in the second family, a maternal great aunt of the proband had characteristic clinical findings, thus making three generations affected. This sequence is best explained by autosomal dominant inheritance with a high degree of specificity. Two other mechanisms for production of PDA seem well established by other studies: (1) maternal rubella and (2) a recessive characteristic. Further family studies are needed to clarify the exact mode of inheritance.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalJAMA - Journal of the American Medical Association
Volume194
Issue number2
DOIs
StatePublished - Oct 11 1965
Externally publishedYes

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Patent Ductus Arteriosus
Mothers
Rubella
Spouses
Fathers

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Patent Ductus Arteriosus : Study of two Families. / Lynch, Henry T.; Grissom, R. L.; Magnuson, C. R.; Krush, A.

In: JAMA - Journal of the American Medical Association, Vol. 194, No. 2, 11.10.1965, p. 135-138.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Grissom, R. L. ; Magnuson, C. R. ; Krush, A. / Patent Ductus Arteriosus : Study of two Families. In: JAMA - Journal of the American Medical Association. 1965 ; Vol. 194, No. 2. pp. 135-138.
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