Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization

Takanari Miyamoto, Hiromichi Yumoto, Yusuke Takahashi, Michael Davey, Frank C. Gibson, Caroline Attardo Genco

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Here we report on early inflammatory events associated with Porphyromonas gingivalis-accelerated atherosclerosis in apolipoprotein E knockout (ApoE -/-) mice. Animals challenged with P. gingivalis presented with increased macrophage infiltration, innate immune marker expression, and atheroma without elevated systemic inflammatory mediators. This early local inflammatory response was prevented in mice immunized with P. gingivalis. We conclude that localized up-regulation of innate immune markers early after infection, rather than systemic inflammation, contributes to pathogen-accelerated atherosclerosis.

Original languageEnglish (US)
Pages (from-to)1376-1380
Number of pages5
JournalInfection and Immunity
Volume74
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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