Pathophysiology of osteoporosis

Robert P. Heaney

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

As with many chronic diseases that express themselves late in life, osteoporosis is distinctly multifactorial both in etiology and in pathophysiology. Osteoporotic fractures occur because of a combination of injury and intrinsic bony fragility. The injury comes most often from a combination of falls, poor postural reflexes that fail to protect bony parts from impact, and reduced soft tissue padding over bony prominences. The bony fragility itself is a composite of geometry, low mass density, severance of microarchitectural connections in trabecular structures, and accumulated fatigue damage. Reduced bone mass, in turn, is caused by varying combinations of gonadal hormone deficiency, inadequate intakes of calcium and vitamin D, decreased physical activity, comorbidity, and the effects of drugs used to treat various unrelated medical conditions. Finally, the often poor outcome from hip fracture in the elderly is partly caused by associated protein- calorie malnutrition. An adequate preventive program for osteoporotic fracture must address as many of these factors as possible, ie, it must be as multifaceted as the disease is multifactorial.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume312
Issue number6
StatePublished - Dec 1996

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Osteoporotic Fractures
Osteoporosis
Preventive Health Services
Gonadal Hormones
Protein-Energy Malnutrition
Hip Fractures
Wounds and Injuries
Vitamin D
Fatigue
Reflex
Comorbidity
Chronic Disease
Exercise
Calcium
Bone and Bones
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Pathophysiology of osteoporosis. / Heaney, Robert P.

In: American Journal of the Medical Sciences, Vol. 312, No. 6, 12.1996, p. 251-256.

Research output: Contribution to journalArticle

Heaney, RP 1996, 'Pathophysiology of osteoporosis', American Journal of the Medical Sciences, vol. 312, no. 6, pp. 251-256.
Heaney, Robert P. / Pathophysiology of osteoporosis. In: American Journal of the Medical Sciences. 1996 ; Vol. 312, No. 6. pp. 251-256.
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