Patient-specific dosimetry of indium-111- and yttrium-90-labeled monoclonal antibody CC49

Peter K. Leichner, Gamal Akabani, David Colcher, Katherine A. Harrison, William G. Hawkins, Miriam Eckblade, Janina Baranowska-Kortylewicz, Samuel C. Augustine, James Wisecarver, Margaret A. Tempero

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The objective of this work was to develop patient-specific dosimetry for patients with metastatic gastrointestinal tract cancers who received 111In-CC49 IgG for imaging before therapy with 90Y-CC49 IgG. Methods: Whole-body imaging of 12 patients, who received 111-185 MBq (3-5 mCi) of 111In-CC49, commenced in <2 hr postinfusion and was continued daily for 4-5 days. SPECT data were acquired at 24 and 72 hr to determine the range of 111In-CC49 activity concentrations in tumors and normal organs. Time- activity curves were generated from the image data and scaled from 111In- CC49 to 90Y-CC49 for dosimetric purposes. Absorbed-dose calculations for 90Y-CC49 included the mean and range in tumor and normal organs. Computed 90Y-CC49 activity concentrations were compared with measurements on 10 needle biopsies of normal liver and tour tumor biopsies. Results: In 9 of 10 normal liver samples, the range of computed 90Y-CC49 activity concentrations bracketed measured values. This was also the case for 3 of 4 tumor biopsies. Absorbed-dose calculations for 90Y-CC49 were based on patients' images and activities in tissue samples and, hence, were patient- specific. Conclusion: For the radiolabeled antibody preparations used in this study, quantitative imaging of 111In-CC49 provided the data required for 90Y-0C49 dosimetry. The range of activities in patients' SPECT images was determined for a meaningful comparison of measured and computed values. Knowledge of activity distributions in tumors and normal organs was essential for computing mean values and ranges of absorbed dose and provided a more complete description of the absorbed dose from 90Y-CC49 than was possible with planar methods.

Original languageEnglish
Pages (from-to)512-516
Number of pages5
JournalJournal of Nuclear Medicine
Volume38
Issue number4
Publication statusPublished - 1997
Externally publishedYes

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology

Cite this

Leichner, P. K., Akabani, G., Colcher, D., Harrison, K. A., Hawkins, W. G., Eckblade, M., ... Tempero, M. A. (1997). Patient-specific dosimetry of indium-111- and yttrium-90-labeled monoclonal antibody CC49. Journal of Nuclear Medicine, 38(4), 512-516.