Abstract
Methacholine challenge tests can be used to establish the presence of bronchial reactivity, and thus provide supportive evidence for a clinical diagnosis of asthma. However, a significant number of pediatric patients may have positive challenge tests, yet not be asthmatic. We determined the degree of bronchial reactivity in a population of children who are siblings of asthmatics. Sixty-three nonasthmatic children, who were part of a Natural History of Asthma study, had a methacholine challenge, completed a respiratory questionnaire, and had skin tests. Thirty-nine of them responded to methacholine with at least a 20% fall in FEV1; 18 had PD20 values less than 200 breath units (bu). The atopic status of the subjects did not influence the degree of methacholine responsiveness. Nonasthmatic siblings of asthmatics had increased nonspecific bronchial reactivity but were not having symptoms of asthma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-109 |
| Number of pages | 7 |
| Journal | Pediatric Asthma, Allergy and Immunology |
| Volume | 1 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1987 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Immunology and Allergy
- Pulmonary and Respiratory Medicine
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Pattern of Methacholine-Induced Bronchial Reactivity in Siblings of Asthmatic Subjects. / Hopp, Russell J.; Bewtra, Againdra K.; Nair, Nicki M.; Biven, Rus E.; Townley, Robert G.
In: Pediatric Asthma, Allergy and Immunology, Vol. 1, No. 2, 1987, p. 103-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pattern of Methacholine-Induced Bronchial Reactivity in Siblings of Asthmatic Subjects
AU - Hopp, Russell J.
AU - Bewtra, Againdra K.
AU - Nair, Nicki M.
AU - Biven, Rus E.
AU - Townley, Robert G.
PY - 1987
Y1 - 1987
N2 - Methacholine challenge tests can be used to establish the presence of bronchial reactivity, and thus provide supportive evidence for a clinical diagnosis of asthma. However, a significant number of pediatric patients may have positive challenge tests, yet not be asthmatic. We determined the degree of bronchial reactivity in a population of children who are siblings of asthmatics. Sixty-three nonasthmatic children, who were part of a Natural History of Asthma study, had a methacholine challenge, completed a respiratory questionnaire, and had skin tests. Thirty-nine of them responded to methacholine with at least a 20% fall in FEV1; 18 had PD20 values less than 200 breath units (bu). The atopic status of the subjects did not influence the degree of methacholine responsiveness. Nonasthmatic siblings of asthmatics had increased nonspecific bronchial reactivity but were not having symptoms of asthma.
AB - Methacholine challenge tests can be used to establish the presence of bronchial reactivity, and thus provide supportive evidence for a clinical diagnosis of asthma. However, a significant number of pediatric patients may have positive challenge tests, yet not be asthmatic. We determined the degree of bronchial reactivity in a population of children who are siblings of asthmatics. Sixty-three nonasthmatic children, who were part of a Natural History of Asthma study, had a methacholine challenge, completed a respiratory questionnaire, and had skin tests. Thirty-nine of them responded to methacholine with at least a 20% fall in FEV1; 18 had PD20 values less than 200 breath units (bu). The atopic status of the subjects did not influence the degree of methacholine responsiveness. Nonasthmatic siblings of asthmatics had increased nonspecific bronchial reactivity but were not having symptoms of asthma.
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U2 - 10.1089/pai.1987.1.103
DO - 10.1089/pai.1987.1.103
M3 - Article
VL - 1
SP - 103
EP - 109
JO - Pediatric, Allergy, Immunology, and Pulmonology
JF - Pediatric, Allergy, Immunology, and Pulmonology
SN - 2151-321X
IS - 2
ER -