Peptide self-assembly at the nanoscale

a challenging target for computational and experimental biotechnology

Giorgio Colombo, Patricia Soto, Ehud Gazit

Research output: Contribution to journalReview article

100 Citations (Scopus)

Abstract

Self-assembly at the nanoscale is becoming increasingly important for the fabrication of novel supramolecular structures, with applications in the fields of nanobiotechnology and nanomedicine. Peptides represent the most favorable building blocks for the design and synthesis of nanostructures because they offer a great diversity of chemical and physical properties, they can be synthesized in large amounts, and can be modified and decorated with functional elements, which can be used in diverse applications. In this article, we review some of the most recent experimental advances in the use of nanoscale self-assembled peptide structures and the theoretical efforts aimed at understanding the microscopic determinants of their formation, stability and conformational properties. The combination of experimental observations and theoretical advances will be fundamental to fully realizing the biotechnological potential of peptide self-organization.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalTrends in Biotechnology
Volume25
Issue number5
DOIs
StatePublished - May 2007

Fingerprint

Biotechnology
Self assembly
Peptides
Nanobiotechnology
Nanomedicine
Medical nanotechnology
Nanostructures
Chemical properties
Physical properties
Fabrication

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Peptide self-assembly at the nanoscale : a challenging target for computational and experimental biotechnology. / Colombo, Giorgio; Soto, Patricia; Gazit, Ehud.

In: Trends in Biotechnology, Vol. 25, No. 5, 05.2007, p. 211-218.

Research output: Contribution to journalReview article

@article{fe82979e0b844b9499b8da0dd6ffb132,
title = "Peptide self-assembly at the nanoscale: a challenging target for computational and experimental biotechnology",
abstract = "Self-assembly at the nanoscale is becoming increasingly important for the fabrication of novel supramolecular structures, with applications in the fields of nanobiotechnology and nanomedicine. Peptides represent the most favorable building blocks for the design and synthesis of nanostructures because they offer a great diversity of chemical and physical properties, they can be synthesized in large amounts, and can be modified and decorated with functional elements, which can be used in diverse applications. In this article, we review some of the most recent experimental advances in the use of nanoscale self-assembled peptide structures and the theoretical efforts aimed at understanding the microscopic determinants of their formation, stability and conformational properties. The combination of experimental observations and theoretical advances will be fundamental to fully realizing the biotechnological potential of peptide self-organization.",
author = "Giorgio Colombo and Patricia Soto and Ehud Gazit",
year = "2007",
month = "5",
doi = "10.1016/j.tibtech.2007.03.004",
language = "English",
volume = "25",
pages = "211--218",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Peptide self-assembly at the nanoscale

T2 - a challenging target for computational and experimental biotechnology

AU - Colombo, Giorgio

AU - Soto, Patricia

AU - Gazit, Ehud

PY - 2007/5

Y1 - 2007/5

N2 - Self-assembly at the nanoscale is becoming increasingly important for the fabrication of novel supramolecular structures, with applications in the fields of nanobiotechnology and nanomedicine. Peptides represent the most favorable building blocks for the design and synthesis of nanostructures because they offer a great diversity of chemical and physical properties, they can be synthesized in large amounts, and can be modified and decorated with functional elements, which can be used in diverse applications. In this article, we review some of the most recent experimental advances in the use of nanoscale self-assembled peptide structures and the theoretical efforts aimed at understanding the microscopic determinants of their formation, stability and conformational properties. The combination of experimental observations and theoretical advances will be fundamental to fully realizing the biotechnological potential of peptide self-organization.

AB - Self-assembly at the nanoscale is becoming increasingly important for the fabrication of novel supramolecular structures, with applications in the fields of nanobiotechnology and nanomedicine. Peptides represent the most favorable building blocks for the design and synthesis of nanostructures because they offer a great diversity of chemical and physical properties, they can be synthesized in large amounts, and can be modified and decorated with functional elements, which can be used in diverse applications. In this article, we review some of the most recent experimental advances in the use of nanoscale self-assembled peptide structures and the theoretical efforts aimed at understanding the microscopic determinants of their formation, stability and conformational properties. The combination of experimental observations and theoretical advances will be fundamental to fully realizing the biotechnological potential of peptide self-organization.

UR - http://www.scopus.com/inward/record.url?scp=34247245185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247245185&partnerID=8YFLogxK

U2 - 10.1016/j.tibtech.2007.03.004

DO - 10.1016/j.tibtech.2007.03.004

M3 - Review article

VL - 25

SP - 211

EP - 218

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

IS - 5

ER -