Perforating Granuloma Annulare in a Patient With Acquired Immunodeficiency Syndrome: Immunohistologic Evaluation of the Cellular Infiltrate

Christopher J. Huerter; Jonathan Bass; Wilma F. Bergfeld; Raymond R. Tubbs

doi:10.1001/archderm.1987.01660330128025

Perforating Granuloma Annulare in a Patient With Acquired Immunodeficiency Syndrome: Immunohistologic Evaluation of the Cellular Infiltrate

Christopher J. Huerter, Jonathan Bass, Wilma F. Bergfeld, Raymond R. Tubbs

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Abstract

The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate—Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltrate to consist predominantly of cytotoxic/suppressor T cells. This finding is a reflection of the patient's altered immune status and calls into question the role of specific T-cell subsets in the pathogenesis of granuloma annulare. (Arch Dermatol 1987;123:1217-1220).

Original language	English (US)
Pages (from-to)	1217-1220
Number of pages	4
Journal	Archives of Dermatology
Volume	123
Issue number	9
DOIs	https://doi.org/10.1001/archderm.1987.01660330128025
State	Published - Sep 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Dermatology

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10.1001/archderm.1987.01660330128025

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title = "Perforating Granuloma Annulare in a Patient With Acquired Immunodeficiency Syndrome: Immunohistologic Evaluation of the Cellular Infiltrate",

abstract = "The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate—Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltrate to consist predominantly of cytotoxic/suppressor T cells. This finding is a reflection of the patient's altered immune status and calls into question the role of specific T-cell subsets in the pathogenesis of granuloma annulare. (Arch Dermatol 1987;123:1217-1220).",

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AU - Tubbs, Raymond R.

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AB - The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate—Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltrate to consist predominantly of cytotoxic/suppressor T cells. This finding is a reflection of the patient's altered immune status and calls into question the role of specific T-cell subsets in the pathogenesis of granuloma annulare. (Arch Dermatol 1987;123:1217-1220).

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Perforating Granuloma Annulare in a Patient With Acquired Immunodeficiency Syndrome: Immunohistologic Evaluation of the Cellular Infiltrate

Abstract

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