Perforating Granuloma Annulare in a Patient With Acquired Immunodeficiency Syndrome: Immunohistologic Evaluation of the Cellular Infiltrate

Christopher J. Huerter, Jonathan Bass, Wilma F. Bergfeld, Raymond R. Tubbs

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The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate—Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltrate to consist predominantly of cytotoxic/suppressor T cells. This finding is a reflection of the patient's altered immune status and calls into question the role of specific T-cell subsets in the pathogenesis of granuloma annulare. (Arch Dermatol 1987;123:1217-1220).

Original languageEnglish (US)
Pages (from-to)1217-1220
Number of pages4
JournalArchives of Dermatology
Issue number9
StatePublished - Sep 1987
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Dermatology

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