Periosteal bone formation stimulated by externally induced bending strains

D. M. Raab-Cullen, Mohammed P. Akhter, D. B. Kimmel, Robert R. Recker

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The rat tibia four-point bending model is a new mechanical loading model in which force is applied through external pads to the rat lower limb. The advantages of the model are controlled force application to a well-defined bone, noninvasive external loading, and the addition of loads to normal daily activity. A disadvantage of the model is that the pads create local pressure on the leg at the contact sites. This study examined the differences in tibial response to bending strains and to local pressure under the pads. A total of 30 adult Sprague-Dawley rats were randomized into three external loading groups: bending, cyclic pressure, and static pressure. The right leg of each rat was externally loaded to create either bending or local pressure without bending; the left leg served as a control. Strains on the lateral surface averaged 1200 με in compression during bending load application and

Original languageEnglish
Pages (from-to)1143-1152
Number of pages10
JournalJournal of Bone and Mineral Research
Volume9
Issue number8
StatePublished - Aug 1994

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Osteogenesis
Pressure
Leg
Tibia
Sprague Dawley Rats
Lower Extremity
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Periosteal bone formation stimulated by externally induced bending strains. / Raab-Cullen, D. M.; Akhter, Mohammed P.; Kimmel, D. B.; Recker, Robert R.

In: Journal of Bone and Mineral Research, Vol. 9, No. 8, 08.1994, p. 1143-1152.

Research output: Contribution to journalArticle

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