Abstract
The rat tibia four-point bending model is a new mechanical loading model in which force is applied through external pads to the rat lower limb. The advantages of the model are controlled force application to a well-defined bone, noninvasive external loading, and the addition of loads to normal daily activity. A disadvantage of the model is that the pads create local pressure on the leg at the contact sites. This study examined the differences in tibial response to bending strains and to local pressure under the pads. A total of 30 adult Sprague-Dawley rats were randomized into three external loading groups: bending, cyclic pressure, and static pressure. The right leg of each rat was externally loaded to create either bending or local pressure without bending; the left leg served as a control. Strains on the lateral surface averaged 1200 με in compression during bending load application and
| Original language | English |
|---|---|
| Pages (from-to) | 1143-1152 |
| Number of pages | 10 |
| Journal | Journal of Bone and Mineral Research |
| Volume | 9 |
| Issue number | 8 |
| State | Published - Aug 1994 |
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All Science Journal Classification (ASJC) codes
- Surgery
Cite this
Periosteal bone formation stimulated by externally induced bending strains. / Raab-Cullen, D. M.; Akhter, Mohammed P.; Kimmel, D. B.; Recker, Robert R.
In: Journal of Bone and Mineral Research, Vol. 9, No. 8, 08.1994, p. 1143-1152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Periosteal bone formation stimulated by externally induced bending strains
AU - Raab-Cullen, D. M.
AU - Akhter, Mohammed P.
AU - Kimmel, D. B.
AU - Recker, Robert R.
PY - 1994/8
Y1 - 1994/8
N2 - The rat tibia four-point bending model is a new mechanical loading model in which force is applied through external pads to the rat lower limb. The advantages of the model are controlled force application to a well-defined bone, noninvasive external loading, and the addition of loads to normal daily activity. A disadvantage of the model is that the pads create local pressure on the leg at the contact sites. This study examined the differences in tibial response to bending strains and to local pressure under the pads. A total of 30 adult Sprague-Dawley rats were randomized into three external loading groups: bending, cyclic pressure, and static pressure. The right leg of each rat was externally loaded to create either bending or local pressure without bending; the left leg served as a control. Strains on the lateral surface averaged 1200 με in compression during bending load application and
AB - The rat tibia four-point bending model is a new mechanical loading model in which force is applied through external pads to the rat lower limb. The advantages of the model are controlled force application to a well-defined bone, noninvasive external loading, and the addition of loads to normal daily activity. A disadvantage of the model is that the pads create local pressure on the leg at the contact sites. This study examined the differences in tibial response to bending strains and to local pressure under the pads. A total of 30 adult Sprague-Dawley rats were randomized into three external loading groups: bending, cyclic pressure, and static pressure. The right leg of each rat was externally loaded to create either bending or local pressure without bending; the left leg served as a control. Strains on the lateral surface averaged 1200 με in compression during bending load application and
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M3 - Article
VL - 9
SP - 1143
EP - 1152
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 8
ER -