Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata, Marina Zelivyanskaya, Jenae Limoges, Kimberly A. Carlson, Santhi Gorantla, Chad Branecki, Shrinivas Bishu, Huangui Xiong, Howard E. Gendelman

Research output: Contribution to journalArticle

28 Scopus citations


Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

Original languageEnglish
Pages (from-to)112-129
Number of pages18
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Sep 2003
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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