Pernicious anemia, the most common cause of megaloblastic anemia, was first described by Thomas Addison in 1849. The condition is associated with human leucocyte antigen (HLA) types A2, A3, and B7, and the type A blood group. In pernicious anemia, abnormal red blood cells are produced resulting in impaired oxygen transport. Murine Models of Autoimmune Gastritis: The identification of gastric H+/K+-ATPase as the target of parietal-cell autoantibodies raises the question of the role of the ATPase in the immunopathogenesis of the gastric lesion. Studies in mice suggest that the lesion of autoimmune gastritis is initiated by CD4 T cells that recognize the beta subunit of gastric H+/K+-ATPase. Organ-specific autoimmune disease, including gastritis, develops in susceptible strains of mice after neonatal thymectomy. Gastritis also develops in neonatal mice treated with ....
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)