Abstract
Physical activity produces many positive physiological changes. Some of these physiological changes, however, can adversely affect the absorption, distribution, metabolism, and/or excretion of certain medications when taken concurrently. Blood flow distribution is fundamental to the study of pharmacokinetics and can vary dramatically during rest compared with exercise. The liver and the kidney play significant roles in calculating the pharmacokinetic parameters of medications. Blood flow to these organs is significant at rest but decreases during exercise. These changes in blood flow, as well as other physiological changes during exercise, have shown to alter the pharmacokinetics of some drugs. Medications that require extra therapeutic monitoring may be affected by this drug-exercise interaction. Health care professionals and patients should be aware of these potential drug-exercise interactions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 226-229 |
| Number of pages | 4 |
| Journal | American Journal of Lifestyle Medicine |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2010 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Health Policy
- Public Health, Environmental and Occupational Health
Cite this
Pharmacokinetic Drug Interactions With Physical Activity. / Lenz, Thomas L.
In: American Journal of Lifestyle Medicine, Vol. 4, No. 3, 2010, p. 226-229.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pharmacokinetic Drug Interactions With Physical Activity
AU - Lenz, Thomas L.
PY - 2010
Y1 - 2010
N2 - Physical activity produces many positive physiological changes. Some of these physiological changes, however, can adversely affect the absorption, distribution, metabolism, and/or excretion of certain medications when taken concurrently. Blood flow distribution is fundamental to the study of pharmacokinetics and can vary dramatically during rest compared with exercise. The liver and the kidney play significant roles in calculating the pharmacokinetic parameters of medications. Blood flow to these organs is significant at rest but decreases during exercise. These changes in blood flow, as well as other physiological changes during exercise, have shown to alter the pharmacokinetics of some drugs. Medications that require extra therapeutic monitoring may be affected by this drug-exercise interaction. Health care professionals and patients should be aware of these potential drug-exercise interactions.
AB - Physical activity produces many positive physiological changes. Some of these physiological changes, however, can adversely affect the absorption, distribution, metabolism, and/or excretion of certain medications when taken concurrently. Blood flow distribution is fundamental to the study of pharmacokinetics and can vary dramatically during rest compared with exercise. The liver and the kidney play significant roles in calculating the pharmacokinetic parameters of medications. Blood flow to these organs is significant at rest but decreases during exercise. These changes in blood flow, as well as other physiological changes during exercise, have shown to alter the pharmacokinetics of some drugs. Medications that require extra therapeutic monitoring may be affected by this drug-exercise interaction. Health care professionals and patients should be aware of these potential drug-exercise interactions.
UR - http://www.scopus.com/inward/record.url?scp=84990365362&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990365362&partnerID=8YFLogxK
U2 - 10.1177/1559827610361565
DO - 10.1177/1559827610361565
M3 - Review article
VL - 4
SP - 226
EP - 229
JO - American Journal of Lifestyle Medicine
JF - American Journal of Lifestyle Medicine
SN - 1559-8276
IS - 3
ER -