Pharmacokinetics of a single, large dose of cholecalciferol

Marium Ilahi, Laura A.G. Armas, Robert P. Heaney

Research output: Contribution to journalArticlepeer-review

171 Scopus citations


Background: There is much interest in dosing vitamin D intermittently for patient convenience and long-term adherence. Objective: The objective was to characterize the time course and response of 25-hydroxyvitamin D (calcidiol) to a large oral dose of cholecalciferol. Design: One group (30 subjects) was supplemented with a single oral dose of 100 000 IU cholecalciferol. A second group (10 subjects) served as a control group to assess the seasonal change of calcidiol. Serum calcidiol concentrations were followed for 4 mo. The subjects were healthy with limited sun exposure (

Original languageEnglish (US)
Pages (from-to)688-691
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Issue number3
StatePublished - Mar 1 2008

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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