Pharmacokinetics of a single, large dose of cholecalciferol

Marium Ilahi; Laura A.G. Armas; Robert P. Heaney

doi:10.1093/ajcn/87.3.688

Pharmacokinetics of a single, large dose of cholecalciferol

Marium Ilahi, Laura A.G. Armas, Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

Background: There is much interest in dosing vitamin D intermittently for patient convenience and long-term adherence. Objective: The objective was to characterize the time course and response of 25-hydroxyvitamin D (calcidiol) to a large oral dose of cholecalciferol. Design: One group (30 subjects) was supplemented with a single oral dose of 100 000 IU cholecalciferol. A second group (10 subjects) served as a control group to assess the seasonal change of calcidiol. Serum calcidiol concentrations were followed for 4 mo. The subjects were healthy with limited sun exposure (

Original language	English (US)
Pages (from-to)	688-691
Number of pages	4
Journal	American Journal of Clinical Nutrition
Volume	87
Issue number	3
DOIs	https://doi.org/10.1093/ajcn/87.3.688
State	Published - Mar 1 2008

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Nutrition and Dietetics

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Pharmacokinetics of a single, large dose of cholecalciferol

Abstract

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