Pharmacokinetics of a single, large dose of cholecalciferol

Marium Ilahi, Laura A G Armas, Robert P. Heaney

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Abstract

Background: There is much interest in dosing vitamin D intermittently for patient convenience and long-term adherence. Objective: The objective was to characterize the time course and response of 25-hydroxyvitamin D (calcidiol) to a large oral dose of cholecalciferol. Design: One group (30 subjects) was supplemented with a single oral dose of 100 000 IU cholecalciferol. A second group (10 subjects) served as a control group to assess the seasonal change of calcidiol. Serum calcidiol concentrations were followed for 4 mo. The subjects were healthy with limited sun exposure (

Original languageEnglish
Pages (from-to)688-691
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number3
Publication statusPublished - Mar 1 2008

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

Ilahi, M., Armas, L. A. G., & Heaney, R. P. (2008). Pharmacokinetics of a single, large dose of cholecalciferol. American Journal of Clinical Nutrition, 87(3), 688-691.