Abstract
A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairment of responding, while rats treated daily after each session did not display tolerance when the drugs were administered before testing. These results indicate that behavioral compensatory mechanisms may be involved in the development of tolerance to the disruptive effects of LSD and mescaline on fixed-ratio (FR-10) performance.
| Original language | English |
|---|---|
| Pages (from-to) | 239-244 |
| Number of pages | 6 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1977 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Pharmacological and behavioral components of tolerance to LSD and mescaline in rats. / Murray, Thomas F.; Craigmill, A. L.; Fischer, G. J.
In: Pharmacology, Biochemistry and Behavior, Vol. 7, No. 3, 1977, p. 239-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacological and behavioral components of tolerance to LSD and mescaline in rats
AU - Murray, Thomas F.
AU - Craigmill, A. L.
AU - Fischer, G. J.
PY - 1977
Y1 - 1977
N2 - A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairment of responding, while rats treated daily after each session did not display tolerance when the drugs were administered before testing. These results indicate that behavioral compensatory mechanisms may be involved in the development of tolerance to the disruptive effects of LSD and mescaline on fixed-ratio (FR-10) performance.
AB - A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairment of responding, while rats treated daily after each session did not display tolerance when the drugs were administered before testing. These results indicate that behavioral compensatory mechanisms may be involved in the development of tolerance to the disruptive effects of LSD and mescaline on fixed-ratio (FR-10) performance.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017652573&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(77)90140-X
DO - 10.1016/0091-3057(77)90140-X
M3 - Article
VL - 7
SP - 239
EP - 244
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 3
ER -