Pharmacological and behavioral components of tolerance to LSD and mescaline in rats

T. F. Murray, A. L. Craigmill, G. J. Fischer

Research output: Contribution to journalArticle

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Abstract

A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairment of responding, while rats treated daily after each session did not display tolerance when the drugs were administered before testing. These results indicate that behavioral compensatory mechanisms may be involved in the development of tolerance to the disruptive effects of LSD and mescaline on fixed-ratio (FR-10) performance.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume7
Issue number3
DOIs
StatePublished - Sep 1977

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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