Pharmacological and behavioral components of tolerance to LSD and mescaline in rats

Thomas F. Murray, A. L. Craigmill, G. J. Fischer

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairment of responding, while rats treated daily after each session did not display tolerance when the drugs were administered before testing. These results indicate that behavioral compensatory mechanisms may be involved in the development of tolerance to the disruptive effects of LSD and mescaline on fixed-ratio (FR-10) performance.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume7
Issue number3
DOIs
StatePublished - 1977
Externally publishedYes

Fingerprint

Mescaline
Lysergic Acid Diethylamide
Rats
Pharmacology
Drug Tolerance
Reinforcement Schedule
Testing
Reinforcement
Water
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Pharmacological and behavioral components of tolerance to LSD and mescaline in rats. / Murray, Thomas F.; Craigmill, A. L.; Fischer, G. J.

In: Pharmacology, Biochemistry and Behavior, Vol. 7, No. 3, 1977, p. 239-244.

Research output: Contribution to journalArticle

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