Pharmacology of the class 111 antiarrhythmic agent sematilide in patients with arrhythmias

Wilson Wong, Harris N. Paviou, Ulrika M. Birgersdotter, Daniel E. Hillernan, Syed M. Mohiuddin, Dan M. Roden

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Abstract

Sematilide, a close structural analog of N-acetylprocainamide, prolongs cardiac action potentials in vitro, whereas it does not depress maximum action potential upstroke slope, a "class III" action. This report outlines an evaluation of the clinical pharmacologic actions of sematilide in 14 patients with chronic high-frequency nonsustained ventricular arrhythmias. In all, 36 intravenous infusions (range 0.15 to 1.5 mg/kg over 15 minutes) were administered in a dose-ranging, placebo-controlled study design. Sematilide prolonged rate-corrected QT (QTc) in a dose- and concentration-related fashion, did not alter PR or QRS, and slowed heart rate at high concentrations (≥2 μg/ml). The relations between dose and total area under the time-concentration curve, dose and peak plasma concentration, and peak plasma concentration and increase in QTc were linear (r = 0.66 to 0.92; p

Original languageEnglish (US)
Pages (from-to)206-212
Number of pages7
JournalThe American Journal of Cardiology
Volume69
Issue number3
DOIs
StatePublished - Jan 15 1992

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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