Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics

Thomas F. Murray; Akira Horita

doi:10.1016/0024-3205(79)90097-3

Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics

Thomas F. Murray, Akira Horita

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Phencyclidine hydrochloride produced a very characteristic and reproducible stereotyped behavioral syndrome in rats. Both the intensity and the duration of the phencyclidine-induced stereotyped behavior are elicited in a dose-dependent manner in the 2-16 mg/kg dose range. The predominant behavior elicited by low doses was repetitive lateral head swaying, while with higher doses circling and backward walking were observed in addition to the head swaying. This behavior was antagonized by the neuroleptic agents chlorpromazine, haloperidol, and pimozide, but not by α- or β-adrenergic blockers. These results indicate that the phencyclidine-induced stereotyped behavior may be mediated by central dopaminergic mechanisms.

Original language	English (US)
Pages (from-to)	2217-2225
Number of pages	9
Journal	Life Sciences
Volume	24
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(79)90097-3
State	Published - Jun 11 1979
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics",

abstract = "Phencyclidine hydrochloride produced a very characteristic and reproducible stereotyped behavioral syndrome in rats. Both the intensity and the duration of the phencyclidine-induced stereotyped behavior are elicited in a dose-dependent manner in the 2-16 mg/kg dose range. The predominant behavior elicited by low doses was repetitive lateral head swaying, while with higher doses circling and backward walking were observed in addition to the head swaying. This behavior was antagonized by the neuroleptic agents chlorpromazine, haloperidol, and pimozide, but not by α- or β-adrenergic blockers. These results indicate that the phencyclidine-induced stereotyped behavior may be mediated by central dopaminergic mechanisms.",

author = "Murray, {Thomas F.} and Akira Horita",

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AU - Murray, Thomas F.

AU - Horita, Akira

N1 - Funding Information: T .F .M . supported by National Institute on Drug Abuse predoctoral fellowship DA 05036 . The authors wish to thank Laurie Stoops for her skillful typing of this manuscript .

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N2 - Phencyclidine hydrochloride produced a very characteristic and reproducible stereotyped behavioral syndrome in rats. Both the intensity and the duration of the phencyclidine-induced stereotyped behavior are elicited in a dose-dependent manner in the 2-16 mg/kg dose range. The predominant behavior elicited by low doses was repetitive lateral head swaying, while with higher doses circling and backward walking were observed in addition to the head swaying. This behavior was antagonized by the neuroleptic agents chlorpromazine, haloperidol, and pimozide, but not by α- or β-adrenergic blockers. These results indicate that the phencyclidine-induced stereotyped behavior may be mediated by central dopaminergic mechanisms.

AB - Phencyclidine hydrochloride produced a very characteristic and reproducible stereotyped behavioral syndrome in rats. Both the intensity and the duration of the phencyclidine-induced stereotyped behavior are elicited in a dose-dependent manner in the 2-16 mg/kg dose range. The predominant behavior elicited by low doses was repetitive lateral head swaying, while with higher doses circling and backward walking were observed in addition to the head swaying. This behavior was antagonized by the neuroleptic agents chlorpromazine, haloperidol, and pimozide, but not by α- or β-adrenergic blockers. These results indicate that the phencyclidine-induced stereotyped behavior may be mediated by central dopaminergic mechanisms.

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