Abstract
Phencyclidine hydrochloride produced a very characteristic and reproducible stereotyped behavioral syndrome in rats. Both the intensity and the duration of the phencyclidine-induced stereotyped behavior are elicited in a dose-dependent manner in the 2-16 mg/kg dose range. The predominant behavior elicited by low doses was repetitive lateral head swaying, while with higher doses circling and backward walking were observed in addition to the head swaying. This behavior was antagonized by the neuroleptic agents chlorpromazine, haloperidol, and pimozide, but not by α- or β-adrenergic blockers. These results indicate that the phencyclidine-induced stereotyped behavior may be mediated by central dopaminergic mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 2217-2225 |
| Number of pages | 9 |
| Journal | Life Sciences |
| Volume | 24 |
| Issue number | 24 |
| DOIs | |
| State | Published - Jun 11 1979 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
Cite this
Phencyclidine-induced stereotyped behavior in rats : Dose response effects and antagonism by neuroleptics. / Murray, Thomas F.; Horita, Akira.
In: Life Sciences, Vol. 24, No. 24, 11.06.1979, p. 2217-2225.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phencyclidine-induced stereotyped behavior in rats
T2 - Dose response effects and antagonism by neuroleptics
AU - Murray, Thomas F.
AU - Horita, Akira
PY - 1979/6/11
Y1 - 1979/6/11
N2 - Phencyclidine hydrochloride produced a very characteristic and reproducible stereotyped behavioral syndrome in rats. Both the intensity and the duration of the phencyclidine-induced stereotyped behavior are elicited in a dose-dependent manner in the 2-16 mg/kg dose range. The predominant behavior elicited by low doses was repetitive lateral head swaying, while with higher doses circling and backward walking were observed in addition to the head swaying. This behavior was antagonized by the neuroleptic agents chlorpromazine, haloperidol, and pimozide, but not by α- or β-adrenergic blockers. These results indicate that the phencyclidine-induced stereotyped behavior may be mediated by central dopaminergic mechanisms.
AB - Phencyclidine hydrochloride produced a very characteristic and reproducible stereotyped behavioral syndrome in rats. Both the intensity and the duration of the phencyclidine-induced stereotyped behavior are elicited in a dose-dependent manner in the 2-16 mg/kg dose range. The predominant behavior elicited by low doses was repetitive lateral head swaying, while with higher doses circling and backward walking were observed in addition to the head swaying. This behavior was antagonized by the neuroleptic agents chlorpromazine, haloperidol, and pimozide, but not by α- or β-adrenergic blockers. These results indicate that the phencyclidine-induced stereotyped behavior may be mediated by central dopaminergic mechanisms.
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U2 - 10.1016/0024-3205(79)90097-3
DO - 10.1016/0024-3205(79)90097-3
M3 - Article
VL - 24
SP - 2217
EP - 2225
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 24
ER -