Phenotypic heterogeneity in multiple myeloma families

Henry T. Lynch, Patrice Watson, Stefano Tarantolo, Peter H. Wiernik, Brigid Quinn-Laquer, Karin Isgur Bergsagel, Laetitia Huiart, O. I. Olopade, Hagay Sobol, Warren Sanger, David Hogg, Dennis Weisenburger

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Purpose: To describe a series of families with familial multiple myeloma (MM). Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM. Patients and Methods: This observational study consisted of 39 families with multiple cases of MM or related disorders from four collaborating research centers. Each center followed its usual family study method. Probands were interviewed, and, when possible, cancers were verified by medical records and pathology review. A working pedigree was compiled on each family. Results: Seventeen families had affected members in two or more generations, and eight families had two or more affected members in a single generation. Four families had two or more members with plasma cell dyscrasias, with or without a single case of MM. In the remaining 10 families, a single MM case occurred with a family history of other cancers. Other cancers observed in family members included hematologic malignancies and solid tumors. In families with MM in multiple generations, there was a decrease in the age at MM diagnosis in successive generations. Conclusion: The study of familial MM may provide insights into the pathogenesis and, ultimately, the control and prevention of MM and related disorders. Population-based epidemiologic studies are crucial, but because of the rarity of familial MM, a concerted case-finding approach may also be fruitful. Therefore, we propose an international consortium to study familial MM, and we invite all interested colleagues to participate.

Original languageEnglish
Pages (from-to)685-693
Number of pages9
JournalJournal of Clinical Oncology
Volume23
Issue number4
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Multiple Myeloma
Neoplasms
Paraproteinemias
Hematologic Neoplasms
Pedigree
Medical Records
Observational Studies
Epidemiologic Studies
Pathology

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Watson, P., Tarantolo, S., Wiernik, P. H., Quinn-Laquer, B., Bergsagel, K. I., ... Weisenburger, D. (2005). Phenotypic heterogeneity in multiple myeloma families. Journal of Clinical Oncology, 23(4), 685-693. https://doi.org/10.1200/JCO.2005.10.126

Phenotypic heterogeneity in multiple myeloma families. / Lynch, Henry T.; Watson, Patrice; Tarantolo, Stefano; Wiernik, Peter H.; Quinn-Laquer, Brigid; Bergsagel, Karin Isgur; Huiart, Laetitia; Olopade, O. I.; Sobol, Hagay; Sanger, Warren; Hogg, David; Weisenburger, Dennis.

In: Journal of Clinical Oncology, Vol. 23, No. 4, 2005, p. 685-693.

Research output: Contribution to journalArticle

Lynch, HT, Watson, P, Tarantolo, S, Wiernik, PH, Quinn-Laquer, B, Bergsagel, KI, Huiart, L, Olopade, OI, Sobol, H, Sanger, W, Hogg, D & Weisenburger, D 2005, 'Phenotypic heterogeneity in multiple myeloma families', Journal of Clinical Oncology, vol. 23, no. 4, pp. 685-693. https://doi.org/10.1200/JCO.2005.10.126
Lynch HT, Watson P, Tarantolo S, Wiernik PH, Quinn-Laquer B, Bergsagel KI et al. Phenotypic heterogeneity in multiple myeloma families. Journal of Clinical Oncology. 2005;23(4):685-693. https://doi.org/10.1200/JCO.2005.10.126
Lynch, Henry T. ; Watson, Patrice ; Tarantolo, Stefano ; Wiernik, Peter H. ; Quinn-Laquer, Brigid ; Bergsagel, Karin Isgur ; Huiart, Laetitia ; Olopade, O. I. ; Sobol, Hagay ; Sanger, Warren ; Hogg, David ; Weisenburger, Dennis. / Phenotypic heterogeneity in multiple myeloma families. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 4. pp. 685-693.
@article{03c6971fd9ea4bae8d4e512fa376d016,
title = "Phenotypic heterogeneity in multiple myeloma families",
abstract = "Purpose: To describe a series of families with familial multiple myeloma (MM). Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM. Patients and Methods: This observational study consisted of 39 families with multiple cases of MM or related disorders from four collaborating research centers. Each center followed its usual family study method. Probands were interviewed, and, when possible, cancers were verified by medical records and pathology review. A working pedigree was compiled on each family. Results: Seventeen families had affected members in two or more generations, and eight families had two or more affected members in a single generation. Four families had two or more members with plasma cell dyscrasias, with or without a single case of MM. In the remaining 10 families, a single MM case occurred with a family history of other cancers. Other cancers observed in family members included hematologic malignancies and solid tumors. In families with MM in multiple generations, there was a decrease in the age at MM diagnosis in successive generations. Conclusion: The study of familial MM may provide insights into the pathogenesis and, ultimately, the control and prevention of MM and related disorders. Population-based epidemiologic studies are crucial, but because of the rarity of familial MM, a concerted case-finding approach may also be fruitful. Therefore, we propose an international consortium to study familial MM, and we invite all interested colleagues to participate.",
author = "Lynch, {Henry T.} and Patrice Watson and Stefano Tarantolo and Wiernik, {Peter H.} and Brigid Quinn-Laquer and Bergsagel, {Karin Isgur} and Laetitia Huiart and Olopade, {O. I.} and Hagay Sobol and Warren Sanger and David Hogg and Dennis Weisenburger",
year = "2005",
doi = "10.1200/JCO.2005.10.126",
language = "English",
volume = "23",
pages = "685--693",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "4",

}

TY - JOUR

T1 - Phenotypic heterogeneity in multiple myeloma families

AU - Lynch, Henry T.

AU - Watson, Patrice

AU - Tarantolo, Stefano

AU - Wiernik, Peter H.

AU - Quinn-Laquer, Brigid

AU - Bergsagel, Karin Isgur

AU - Huiart, Laetitia

AU - Olopade, O. I.

AU - Sobol, Hagay

AU - Sanger, Warren

AU - Hogg, David

AU - Weisenburger, Dennis

PY - 2005

Y1 - 2005

N2 - Purpose: To describe a series of families with familial multiple myeloma (MM). Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM. Patients and Methods: This observational study consisted of 39 families with multiple cases of MM or related disorders from four collaborating research centers. Each center followed its usual family study method. Probands were interviewed, and, when possible, cancers were verified by medical records and pathology review. A working pedigree was compiled on each family. Results: Seventeen families had affected members in two or more generations, and eight families had two or more affected members in a single generation. Four families had two or more members with plasma cell dyscrasias, with or without a single case of MM. In the remaining 10 families, a single MM case occurred with a family history of other cancers. Other cancers observed in family members included hematologic malignancies and solid tumors. In families with MM in multiple generations, there was a decrease in the age at MM diagnosis in successive generations. Conclusion: The study of familial MM may provide insights into the pathogenesis and, ultimately, the control and prevention of MM and related disorders. Population-based epidemiologic studies are crucial, but because of the rarity of familial MM, a concerted case-finding approach may also be fruitful. Therefore, we propose an international consortium to study familial MM, and we invite all interested colleagues to participate.

AB - Purpose: To describe a series of families with familial multiple myeloma (MM). Observations were used to generate hypotheses about the role of genetic factors, the mode of inheritance of these factors, and the association of other cancers with familial MM. Patients and Methods: This observational study consisted of 39 families with multiple cases of MM or related disorders from four collaborating research centers. Each center followed its usual family study method. Probands were interviewed, and, when possible, cancers were verified by medical records and pathology review. A working pedigree was compiled on each family. Results: Seventeen families had affected members in two or more generations, and eight families had two or more affected members in a single generation. Four families had two or more members with plasma cell dyscrasias, with or without a single case of MM. In the remaining 10 families, a single MM case occurred with a family history of other cancers. Other cancers observed in family members included hematologic malignancies and solid tumors. In families with MM in multiple generations, there was a decrease in the age at MM diagnosis in successive generations. Conclusion: The study of familial MM may provide insights into the pathogenesis and, ultimately, the control and prevention of MM and related disorders. Population-based epidemiologic studies are crucial, but because of the rarity of familial MM, a concerted case-finding approach may also be fruitful. Therefore, we propose an international consortium to study familial MM, and we invite all interested colleagues to participate.

UR - http://www.scopus.com/inward/record.url?scp=20044364347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20044364347&partnerID=8YFLogxK

U2 - 10.1200/JCO.2005.10.126

DO - 10.1200/JCO.2005.10.126

M3 - Article

VL - 23

SP - 685

EP - 693

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 4

ER -