Phenotypic variation in colorectal adenoma/cancer expression in two families. Hereditary flat adenoma syndrome

Henry T. Lynch, T. C. Smyrk, Stephen J. Lanspa, P. M. Lynch, P. Watson, P. C. Strayhorn, E. K. Bronson, J. F. Lynch, I. A. Priluck, H. D. Appelman

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Abstract

Clinical, pathologic, and genetic studies on two colorectal cancer-prone families have disclosed right-sided colonic flat adenomas and colorectal cancer. Adenomatous polyp counts exceeded those found in hereditary nonpolyposis colorectal cancer (HNPCC) but were fewer than in familial adenomatous polyposis (FAP). Colon cancer occurred at a later age than in HNPCC or FAP and showed right-sided predominance. The older age of patients with colonic cancer, the right-sided predominance of colon cancer, and the paucity of rectal adenomas make FAP unlikely. Vertical transmission of polyps and colon cancer fit the pattern of autosomal dominant inheritance. A characteristic feature of this phenotype is the predominance of flat adenomas. Molecular genetic studies, with careful description of phenotype, should help clarify classification.

Original languageEnglish
Pages (from-to)909-915
Number of pages7
JournalCancer
Volume66
Issue number5
StatePublished - 1990

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Adenoma
Colonic Neoplasms
Adenomatous Polyposis Coli
Colorectal Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Phenotype
Adenomatous Polyps
Polyps
Molecular Biology

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Smyrk, T. C., Lanspa, S. J., Lynch, P. M., Watson, P., Strayhorn, P. C., ... Appelman, H. D. (1990). Phenotypic variation in colorectal adenoma/cancer expression in two families. Hereditary flat adenoma syndrome. Cancer, 66(5), 909-915.

Phenotypic variation in colorectal adenoma/cancer expression in two families. Hereditary flat adenoma syndrome. / Lynch, Henry T.; Smyrk, T. C.; Lanspa, Stephen J.; Lynch, P. M.; Watson, P.; Strayhorn, P. C.; Bronson, E. K.; Lynch, J. F.; Priluck, I. A.; Appelman, H. D.

In: Cancer, Vol. 66, No. 5, 1990, p. 909-915.

Research output: Contribution to journalArticle

Lynch, HT, Smyrk, TC, Lanspa, SJ, Lynch, PM, Watson, P, Strayhorn, PC, Bronson, EK, Lynch, JF, Priluck, IA & Appelman, HD 1990, 'Phenotypic variation in colorectal adenoma/cancer expression in two families. Hereditary flat adenoma syndrome', Cancer, vol. 66, no. 5, pp. 909-915.
Lynch, Henry T. ; Smyrk, T. C. ; Lanspa, Stephen J. ; Lynch, P. M. ; Watson, P. ; Strayhorn, P. C. ; Bronson, E. K. ; Lynch, J. F. ; Priluck, I. A. ; Appelman, H. D. / Phenotypic variation in colorectal adenoma/cancer expression in two families. Hereditary flat adenoma syndrome. In: Cancer. 1990 ; Vol. 66, No. 5. pp. 909-915.
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