Phenotypic variation in hereditary adenomatosis: Unusual tumor spectrum

Henry T. Lynch, Thomas A. Ruma, William A. Albano, Jane F. Lynch, Patrick M. Lynch

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Familial adenomatous polyposis coli is a heterogeneous disease with respect to genetics as well as its colonic polyposis and cancer phenotype. The authors report a family with variation in phenotypic expression of polyps ranging from isolated polyps to florid carpeting of the entire colonic mucosal surface. In addition to early-onset colonic cancer, a patient with isolated polyps had a seminoma and subsequently developed gastroesophageal cancer. His son, also with isolated colonic polyps, manifested a pararectal rhabdomyosarcoma. The significance of these variations can only be assessed fully through the study of cancer of all anatomic sites in many additional families.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalDiseases of the Colon & Rectum
Volume25
Issue number3
DOIs
StatePublished - Apr 1 1982

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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