Phenotypic variation in hereditary adenomatosis

Unusual tumor spectrum

Henry T. Lynch, Thomas A. Ruma, William A. Albano, Jane F. Lynch, Patrick M. Lynch

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Familial adenomatous polyposis coli is a heterogeneous disease with respect to genetics as well as its colonic polyposis and cancer phenotype. The authors report a family with variation in phenotypic expression of polyps ranging from isolated polyps to florid carpeting of the entire colonic mucosal surface. In addition to early-onset colonic cancer, a patient with isolated polyps had a seminoma and subsequently developed gastroesophageal cancer. His son, also with isolated colonic polyps, manifested a pararectal rhabdomyosarcoma. The significance of these variations can only be assessed fully through the study of cancer of all anatomic sites in many additional families.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalDiseases of the Colon and Rectum
Volume25
Issue number3
DOIs
StatePublished - Apr 1982

Fingerprint

Polyps
Colonic Neoplasms
Colonic Polyps
Neoplasms
Seminoma
Adenomatous Polyposis Coli
Rhabdomyosarcoma
Nuclear Family
Phenotype

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Phenotypic variation in hereditary adenomatosis : Unusual tumor spectrum. / Lynch, Henry T.; Ruma, Thomas A.; Albano, William A.; Lynch, Jane F.; Lynch, Patrick M.

In: Diseases of the Colon and Rectum, Vol. 25, No. 3, 04.1982, p. 235-238.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Ruma, Thomas A. ; Albano, William A. ; Lynch, Jane F. ; Lynch, Patrick M. / Phenotypic variation in hereditary adenomatosis : Unusual tumor spectrum. In: Diseases of the Colon and Rectum. 1982 ; Vol. 25, No. 3. pp. 235-238.
@article{33a781d551aa485b88141e473c4130a7,
title = "Phenotypic variation in hereditary adenomatosis: Unusual tumor spectrum",
abstract = "Familial adenomatous polyposis coli is a heterogeneous disease with respect to genetics as well as its colonic polyposis and cancer phenotype. The authors report a family with variation in phenotypic expression of polyps ranging from isolated polyps to florid carpeting of the entire colonic mucosal surface. In addition to early-onset colonic cancer, a patient with isolated polyps had a seminoma and subsequently developed gastroesophageal cancer. His son, also with isolated colonic polyps, manifested a pararectal rhabdomyosarcoma. The significance of these variations can only be assessed fully through the study of cancer of all anatomic sites in many additional families.",
author = "Lynch, {Henry T.} and Ruma, {Thomas A.} and Albano, {William A.} and Lynch, {Jane F.} and Lynch, {Patrick M.}",
year = "1982",
month = "4",
doi = "10.1007/BF02553113",
language = "English",
volume = "25",
pages = "235--238",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Phenotypic variation in hereditary adenomatosis

T2 - Unusual tumor spectrum

AU - Lynch, Henry T.

AU - Ruma, Thomas A.

AU - Albano, William A.

AU - Lynch, Jane F.

AU - Lynch, Patrick M.

PY - 1982/4

Y1 - 1982/4

N2 - Familial adenomatous polyposis coli is a heterogeneous disease with respect to genetics as well as its colonic polyposis and cancer phenotype. The authors report a family with variation in phenotypic expression of polyps ranging from isolated polyps to florid carpeting of the entire colonic mucosal surface. In addition to early-onset colonic cancer, a patient with isolated polyps had a seminoma and subsequently developed gastroesophageal cancer. His son, also with isolated colonic polyps, manifested a pararectal rhabdomyosarcoma. The significance of these variations can only be assessed fully through the study of cancer of all anatomic sites in many additional families.

AB - Familial adenomatous polyposis coli is a heterogeneous disease with respect to genetics as well as its colonic polyposis and cancer phenotype. The authors report a family with variation in phenotypic expression of polyps ranging from isolated polyps to florid carpeting of the entire colonic mucosal surface. In addition to early-onset colonic cancer, a patient with isolated polyps had a seminoma and subsequently developed gastroesophageal cancer. His son, also with isolated colonic polyps, manifested a pararectal rhabdomyosarcoma. The significance of these variations can only be assessed fully through the study of cancer of all anatomic sites in many additional families.

UR - http://www.scopus.com/inward/record.url?scp=0020035278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020035278&partnerID=8YFLogxK

U2 - 10.1007/BF02553113

DO - 10.1007/BF02553113

M3 - Article

VL - 25

SP - 235

EP - 238

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 3

ER -