Phenotypic variation in hereditary adenomatosis: Unusual tumor spectrum

Henry T. Lynch, Thomas A. Ruma, William A. Albano, Jane F. Lynch, Patrick M. Lynch

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Abstract

Familial adenomatous polyposis coli is a heterogeneous disease with respect to genetics as well as its colonic polyposis and cancer phenotype. The authors report a family with variation in phenotypic expression of polyps ranging from isolated polyps to florid carpeting of the entire colonic mucosal surface. In addition to early-onset colonic cancer, a patient with isolated polyps had a seminoma and subsequently developed gastroesophageal cancer. His son, also with isolated colonic polyps, manifested a pararectal rhabdomyosarcoma. The significance of these variations can only be assessed fully through the study of cancer of all anatomic sites in many additional families.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalDiseases of the Colon & Rectum
Volume25
Issue number3
DOIs
StatePublished - Apr 1 1982

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All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Lynch, H. T., Ruma, T. A., Albano, W. A., Lynch, J. F., & Lynch, P. M. (1982). Phenotypic variation in hereditary adenomatosis: Unusual tumor spectrum. Diseases of the Colon & Rectum, 25(3), 235-238. https://doi.org/10.1007/BF02553113