Phosphorus

Robert P. Heaney

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Phosphorus, as phosphate, is essential for all life and is widely distributed in both plant and animal foods. A diet adequate in other nutrients, particularly calcium and protein, will automatically be adequate in phosphorus. ECF [Pi], which varies little with dietary phosphorus intake, is itself vital for normal physiological function in all the higher vertebrates, and the principal abnormalities of phosphate metabolism involve either excessively low or excessively high concentrations of this critical anion. ECF [Pi] is regulated by a feedback control loop in which fibroblast growth factor -23 (FGF -23) is the effector hormone. Low serum phosphorus is most commonly due to increased renal phosphorus clearance produced by high levels of parathyroid hormone or FGF -23. The result is rickets or osteomalacia as well as muscle weakness and general metabolic dysfunction of all body tissues and organs. High serum phosphorus is most commonly due to decreased renal clearance as a result of kidney failure. The results include extra -osseous calcification, especially of critical arterial systems.

Original languageEnglish
Title of host publicationPresent Knowledge in Nutrition: Tenth Edition
PublisherWiley-Blackwell
Pages447-458
Number of pages12
ISBN (Print)9780470959176
DOIs
StatePublished - Jun 18 2012

Fingerprint

Phosphorus
Dietary Phosphorus
Phosphates
Kidney
Osteomalacia
Rickets
Edible Plants
Muscle Weakness
Parathyroid Hormone
Serum
Renal Insufficiency
Anions
Vertebrates
Hormones
Diet
Calcium
Food
Proteins
fibroblast growth factor 23

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Heaney, R. P. (2012). Phosphorus. In Present Knowledge in Nutrition: Tenth Edition (pp. 447-458). Wiley-Blackwell. https://doi.org/10.1002/9781119946045.ch29

Phosphorus. / Heaney, Robert P.

Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, 2012. p. 447-458.

Research output: Chapter in Book/Report/Conference proceedingChapter

Heaney, RP 2012, Phosphorus. in Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, pp. 447-458. https://doi.org/10.1002/9781119946045.ch29
Heaney RP. Phosphorus. In Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell. 2012. p. 447-458 https://doi.org/10.1002/9781119946045.ch29
Heaney, Robert P. / Phosphorus. Present Knowledge in Nutrition: Tenth Edition. Wiley-Blackwell, 2012. pp. 447-458
@inbook{0bff11a726344e1cb5b6de7b38a27dfb,
title = "Phosphorus",
abstract = "Phosphorus, as phosphate, is essential for all life and is widely distributed in both plant and animal foods. A diet adequate in other nutrients, particularly calcium and protein, will automatically be adequate in phosphorus. ECF [Pi], which varies little with dietary phosphorus intake, is itself vital for normal physiological function in all the higher vertebrates, and the principal abnormalities of phosphate metabolism involve either excessively low or excessively high concentrations of this critical anion. ECF [Pi] is regulated by a feedback control loop in which fibroblast growth factor -23 (FGF -23) is the effector hormone. Low serum phosphorus is most commonly due to increased renal phosphorus clearance produced by high levels of parathyroid hormone or FGF -23. The result is rickets or osteomalacia as well as muscle weakness and general metabolic dysfunction of all body tissues and organs. High serum phosphorus is most commonly due to decreased renal clearance as a result of kidney failure. The results include extra -osseous calcification, especially of critical arterial systems.",
author = "Heaney, {Robert P.}",
year = "2012",
month = "6",
day = "18",
doi = "10.1002/9781119946045.ch29",
language = "English",
isbn = "9780470959176",
pages = "447--458",
booktitle = "Present Knowledge in Nutrition: Tenth Edition",
publisher = "Wiley-Blackwell",
address = "United Kingdom",

}

TY - CHAP

T1 - Phosphorus

AU - Heaney, Robert P.

PY - 2012/6/18

Y1 - 2012/6/18

N2 - Phosphorus, as phosphate, is essential for all life and is widely distributed in both plant and animal foods. A diet adequate in other nutrients, particularly calcium and protein, will automatically be adequate in phosphorus. ECF [Pi], which varies little with dietary phosphorus intake, is itself vital for normal physiological function in all the higher vertebrates, and the principal abnormalities of phosphate metabolism involve either excessively low or excessively high concentrations of this critical anion. ECF [Pi] is regulated by a feedback control loop in which fibroblast growth factor -23 (FGF -23) is the effector hormone. Low serum phosphorus is most commonly due to increased renal phosphorus clearance produced by high levels of parathyroid hormone or FGF -23. The result is rickets or osteomalacia as well as muscle weakness and general metabolic dysfunction of all body tissues and organs. High serum phosphorus is most commonly due to decreased renal clearance as a result of kidney failure. The results include extra -osseous calcification, especially of critical arterial systems.

AB - Phosphorus, as phosphate, is essential for all life and is widely distributed in both plant and animal foods. A diet adequate in other nutrients, particularly calcium and protein, will automatically be adequate in phosphorus. ECF [Pi], which varies little with dietary phosphorus intake, is itself vital for normal physiological function in all the higher vertebrates, and the principal abnormalities of phosphate metabolism involve either excessively low or excessively high concentrations of this critical anion. ECF [Pi] is regulated by a feedback control loop in which fibroblast growth factor -23 (FGF -23) is the effector hormone. Low serum phosphorus is most commonly due to increased renal phosphorus clearance produced by high levels of parathyroid hormone or FGF -23. The result is rickets or osteomalacia as well as muscle weakness and general metabolic dysfunction of all body tissues and organs. High serum phosphorus is most commonly due to decreased renal clearance as a result of kidney failure. The results include extra -osseous calcification, especially of critical arterial systems.

UR - http://www.scopus.com/inward/record.url?scp=84886956444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886956444&partnerID=8YFLogxK

U2 - 10.1002/9781119946045.ch29

DO - 10.1002/9781119946045.ch29

M3 - Chapter

SN - 9780470959176

SP - 447

EP - 458

BT - Present Knowledge in Nutrition: Tenth Edition

PB - Wiley-Blackwell

ER -