Phylogenetic distribution of [3H]cyclohexyladenosine binding sites in nervous tissue

Joseph F. Siebenaller, Thomas F. Murray

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The specific binding of the A1 adenosine receptor ligand, [3H]CHA, was investigated in membrane fractions prepared from brains of eleven vertebrate species and ganglia of four invertebrate species. Substantial amounts of specific [3H]CHA binding sites were demonstrated in brain membranes of all vertebrate species examined; however, [3H]CHA binding sites were not detectable in nervous tissue of the invertebrate species studied. The densities of [3H]CHA binding sites in vertebrate brains increase in higher vertebrates. Moreover, the pharmacological characteristics of the site labeled by [3H]CHA in two divergent classes of vertebrates were similar. The broad phylogenetic distribution of A1 adenosine receptors in primitive as well as advanced vertebrate species suggests a fundamental role for adenosine in neuronal modulation.

Original languageEnglish
Pages (from-to)182-189
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume137
Issue number1
DOIs
StatePublished - May 29 1986
Externally publishedYes

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Nerve Tissue
Adenosine A1 Receptors
Vertebrates
Brain
Binding Sites
Tissue
Membranes
Invertebrate Ganglia
Adenosine
Modulation
Ligands
Invertebrates
Pharmacology

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Phylogenetic distribution of [3H]cyclohexyladenosine binding sites in nervous tissue. / Siebenaller, Joseph F.; Murray, Thomas F.

In: Biochemical and Biophysical Research Communications, Vol. 137, No. 1, 29.05.1986, p. 182-189.

Research output: Contribution to journalArticle

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