Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Jacqueline Lammert, Jan Lubinski, Jacek Gronwald, Tomasz Huzarski, Susan Armel, Andrea Eisen, Wendy S. Meschino, Henry T. Lynch, Carrie Snyder, Charis Eng, Olufunmilayo I. Olopade, Ophira Ginsburg, William D. Foulkes, Christine Elser, Stephanie A. Cohen, Marion Kiechle, Steven A. Narod, Joanne Kotsopoulos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Physical activity is inversely associated with the risk of breast cancer among women in the general population. It is not clear whether or not physical activity is associated with the risk of BRCA-associated breast cancer. Methods: We conducted a case–control study of 443 matched pairs of BRCA mutation carriers to evaluate the association between physical activity and breast cancer risk. Moderate and vigorous physical activities at ages 12–13, ages 14–17, ages 18–22, ages 23–29 and ages 30–34 were determined using the Nurses’ Health Study II Physical Activity Questionnaire. We estimated mean metabolic equivalent task hours/week for moderate, vigorous and total physical activities overall (ages 12–34), during adolescence (ages 12–17) and during early adulthood (ages 18–34). Logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for total, moderate and strenuous recreational physical activities and breast cancer risk, by menopausal status. Results: Overall, there was no significant association between total physical activity and subsequent breast cancer risk (ORQ4 vs. Q1 = 1.01, 95% CI 0.69–1.47; P-trend = 0.72). Moderate physical activity between ages 12–17 was associated with a 38% decreased risk of premenopausal breast cancer (ORQ4 vs. Q1 = 0.62; 95% CI 0.40–0.96; P-trend = 0.01). We found no association between exercise and breast cancer diagnosed after menopause. Conclusions: These findings suggest that early-life physical activity is associated with a reduced risk of premenopausal breast cancer among BRCA mutation carriers. Impact: Future prospective analyses, complemented by mechanistic evidence, are warranted in this high-risk population.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalBreast Cancer Research and Treatment
DOIs
StateAccepted/In press - Feb 5 2018

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Exercise
Breast Neoplasms
Mutation
Confidence Intervals
Metabolic Equivalent
Menopause
Population
Logistic Models
Odds Ratio
Nurses
Regression Analysis
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. / Lammert, Jacqueline; Lubinski, Jan; Gronwald, Jacek; Huzarski, Tomasz; Armel, Susan; Eisen, Andrea; Meschino, Wendy S.; Lynch, Henry T.; Snyder, Carrie; Eng, Charis; Olopade, Olufunmilayo I.; Ginsburg, Ophira; Foulkes, William D.; Elser, Christine; Cohen, Stephanie A.; Kiechle, Marion; Narod, Steven A.; Kotsopoulos, Joanne.

In: Breast Cancer Research and Treatment, 05.02.2018, p. 1-11.

Research output: Contribution to journalArticle

Lammert, J, Lubinski, J, Gronwald, J, Huzarski, T, Armel, S, Eisen, A, Meschino, WS, Lynch, HT, Snyder, C, Eng, C, Olopade, OI, Ginsburg, O, Foulkes, WD, Elser, C, Cohen, SA, Kiechle, M, Narod, SA & Kotsopoulos, J 2018, 'Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers', Breast Cancer Research and Treatment, pp. 1-11. https://doi.org/10.1007/s10549-018-4694-1
Lammert, Jacqueline ; Lubinski, Jan ; Gronwald, Jacek ; Huzarski, Tomasz ; Armel, Susan ; Eisen, Andrea ; Meschino, Wendy S. ; Lynch, Henry T. ; Snyder, Carrie ; Eng, Charis ; Olopade, Olufunmilayo I. ; Ginsburg, Ophira ; Foulkes, William D. ; Elser, Christine ; Cohen, Stephanie A. ; Kiechle, Marion ; Narod, Steven A. ; Kotsopoulos, Joanne. / Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. In: Breast Cancer Research and Treatment. 2018 ; pp. 1-11.
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abstract = "Background: Physical activity is inversely associated with the risk of breast cancer among women in the general population. It is not clear whether or not physical activity is associated with the risk of BRCA-associated breast cancer. Methods: We conducted a case–control study of 443 matched pairs of BRCA mutation carriers to evaluate the association between physical activity and breast cancer risk. Moderate and vigorous physical activities at ages 12–13, ages 14–17, ages 18–22, ages 23–29 and ages 30–34 were determined using the Nurses’ Health Study II Physical Activity Questionnaire. We estimated mean metabolic equivalent task hours/week for moderate, vigorous and total physical activities overall (ages 12–34), during adolescence (ages 12–17) and during early adulthood (ages 18–34). Logistic regression analysis was used to estimate the odds ratios (OR) and 95{\%} confidence intervals (CI) for total, moderate and strenuous recreational physical activities and breast cancer risk, by menopausal status. Results: Overall, there was no significant association between total physical activity and subsequent breast cancer risk (ORQ4 vs. Q1 = 1.01, 95{\%} CI 0.69–1.47; P-trend = 0.72). Moderate physical activity between ages 12–17 was associated with a 38{\%} decreased risk of premenopausal breast cancer (ORQ4 vs. Q1 = 0.62; 95{\%} CI 0.40–0.96; P-trend = 0.01). We found no association between exercise and breast cancer diagnosed after menopause. Conclusions: These findings suggest that early-life physical activity is associated with a reduced risk of premenopausal breast cancer among BRCA mutation carriers. Impact: Future prospective analyses, complemented by mechanistic evidence, are warranted in this high-risk population.",
author = "Jacqueline Lammert and Jan Lubinski and Jacek Gronwald and Tomasz Huzarski and Susan Armel and Andrea Eisen and Meschino, {Wendy S.} and Lynch, {Henry T.} and Carrie Snyder and Charis Eng and Olopade, {Olufunmilayo I.} and Ophira Ginsburg and Foulkes, {William D.} and Christine Elser and Cohen, {Stephanie A.} and Marion Kiechle and Narod, {Steven A.} and Joanne Kotsopoulos",
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T1 - Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

AU - Lammert, Jacqueline

AU - Lubinski, Jan

AU - Gronwald, Jacek

AU - Huzarski, Tomasz

AU - Armel, Susan

AU - Eisen, Andrea

AU - Meschino, Wendy S.

AU - Lynch, Henry T.

AU - Snyder, Carrie

AU - Eng, Charis

AU - Olopade, Olufunmilayo I.

AU - Ginsburg, Ophira

AU - Foulkes, William D.

AU - Elser, Christine

AU - Cohen, Stephanie A.

AU - Kiechle, Marion

AU - Narod, Steven A.

AU - Kotsopoulos, Joanne

PY - 2018/2/5

Y1 - 2018/2/5

N2 - Background: Physical activity is inversely associated with the risk of breast cancer among women in the general population. It is not clear whether or not physical activity is associated with the risk of BRCA-associated breast cancer. Methods: We conducted a case–control study of 443 matched pairs of BRCA mutation carriers to evaluate the association between physical activity and breast cancer risk. Moderate and vigorous physical activities at ages 12–13, ages 14–17, ages 18–22, ages 23–29 and ages 30–34 were determined using the Nurses’ Health Study II Physical Activity Questionnaire. We estimated mean metabolic equivalent task hours/week for moderate, vigorous and total physical activities overall (ages 12–34), during adolescence (ages 12–17) and during early adulthood (ages 18–34). Logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for total, moderate and strenuous recreational physical activities and breast cancer risk, by menopausal status. Results: Overall, there was no significant association between total physical activity and subsequent breast cancer risk (ORQ4 vs. Q1 = 1.01, 95% CI 0.69–1.47; P-trend = 0.72). Moderate physical activity between ages 12–17 was associated with a 38% decreased risk of premenopausal breast cancer (ORQ4 vs. Q1 = 0.62; 95% CI 0.40–0.96; P-trend = 0.01). We found no association between exercise and breast cancer diagnosed after menopause. Conclusions: These findings suggest that early-life physical activity is associated with a reduced risk of premenopausal breast cancer among BRCA mutation carriers. Impact: Future prospective analyses, complemented by mechanistic evidence, are warranted in this high-risk population.

AB - Background: Physical activity is inversely associated with the risk of breast cancer among women in the general population. It is not clear whether or not physical activity is associated with the risk of BRCA-associated breast cancer. Methods: We conducted a case–control study of 443 matched pairs of BRCA mutation carriers to evaluate the association between physical activity and breast cancer risk. Moderate and vigorous physical activities at ages 12–13, ages 14–17, ages 18–22, ages 23–29 and ages 30–34 were determined using the Nurses’ Health Study II Physical Activity Questionnaire. We estimated mean metabolic equivalent task hours/week for moderate, vigorous and total physical activities overall (ages 12–34), during adolescence (ages 12–17) and during early adulthood (ages 18–34). Logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for total, moderate and strenuous recreational physical activities and breast cancer risk, by menopausal status. Results: Overall, there was no significant association between total physical activity and subsequent breast cancer risk (ORQ4 vs. Q1 = 1.01, 95% CI 0.69–1.47; P-trend = 0.72). Moderate physical activity between ages 12–17 was associated with a 38% decreased risk of premenopausal breast cancer (ORQ4 vs. Q1 = 0.62; 95% CI 0.40–0.96; P-trend = 0.01). We found no association between exercise and breast cancer diagnosed after menopause. Conclusions: These findings suggest that early-life physical activity is associated with a reduced risk of premenopausal breast cancer among BRCA mutation carriers. Impact: Future prospective analyses, complemented by mechanistic evidence, are warranted in this high-risk population.

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