Abstract
Solid lipid nanoparticles (SLNs) are gaining importance due to numerous advantages they offer as a drug delivery system. SLN incorporate poorly soluble drugs, proteins, biologicals, etc. SLN are prepared by techniques like high-pressure homogenization, sonication and employs a wide range of lipids and surfactants. Physicochemical characterization techniques include particle size analysis, zeta potential and determination of crystallinity/polymorphism. Furthermore, drug loading and drug entrapment efficiency are common parameters used to test the efficiency of SLN. Most importantly, the functionality assay of SLN is essential to predict the activity and performance in vivo. The review presented discusses the importance of SLN in drug delivery with emphasis on principles and limitations associated with their physicochemical characterization.
| Original language | English |
|---|---|
| Pages (from-to) | 1565-1575 |
| Number of pages | 11 |
| Journal | Drug Development and Industrial Pharmacy |
| Volume | 40 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2014 |
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All Science Journal Classification (ASJC) codes
- Drug Discovery
- Pharmacology
- Organic Chemistry
- Medicine(all)
Cite this
Physicochemical characterization techniques for solid lipid nanoparticles : Principles and limitations. / Kathe, Niranjan; Henriksen, Brian; Chauhan, Harsh.
In: Drug Development and Industrial Pharmacy, Vol. 40, No. 12, 01.12.2014, p. 1565-1575.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physicochemical characterization techniques for solid lipid nanoparticles
T2 - Principles and limitations
AU - Kathe, Niranjan
AU - Henriksen, Brian
AU - Chauhan, Harsh
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Solid lipid nanoparticles (SLNs) are gaining importance due to numerous advantages they offer as a drug delivery system. SLN incorporate poorly soluble drugs, proteins, biologicals, etc. SLN are prepared by techniques like high-pressure homogenization, sonication and employs a wide range of lipids and surfactants. Physicochemical characterization techniques include particle size analysis, zeta potential and determination of crystallinity/polymorphism. Furthermore, drug loading and drug entrapment efficiency are common parameters used to test the efficiency of SLN. Most importantly, the functionality assay of SLN is essential to predict the activity and performance in vivo. The review presented discusses the importance of SLN in drug delivery with emphasis on principles and limitations associated with their physicochemical characterization.
AB - Solid lipid nanoparticles (SLNs) are gaining importance due to numerous advantages they offer as a drug delivery system. SLN incorporate poorly soluble drugs, proteins, biologicals, etc. SLN are prepared by techniques like high-pressure homogenization, sonication and employs a wide range of lipids and surfactants. Physicochemical characterization techniques include particle size analysis, zeta potential and determination of crystallinity/polymorphism. Furthermore, drug loading and drug entrapment efficiency are common parameters used to test the efficiency of SLN. Most importantly, the functionality assay of SLN is essential to predict the activity and performance in vivo. The review presented discusses the importance of SLN in drug delivery with emphasis on principles and limitations associated with their physicochemical characterization.
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UR - http://www.scopus.com/inward/citedby.url?scp=84922226591&partnerID=8YFLogxK
U2 - 10.3109/03639045.2014.909840
DO - 10.3109/03639045.2014.909840
M3 - Article
C2 - 24766553
AN - SCOPUS:84922226591
VL - 40
SP - 1565
EP - 1575
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
SN - 0363-9045
IS - 12
ER -