Physicochemical characterization techniques for solid lipid nanoparticles: Principles and limitations

Niranjan Kathe, Brian Henriksen, Harsh Chauhan

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Solid lipid nanoparticles (SLNs) are gaining importance due to numerous advantages they offer as a drug delivery system. SLN incorporate poorly soluble drugs, proteins, biologicals, etc. SLN are prepared by techniques like high-pressure homogenization, sonication and employs a wide range of lipids and surfactants. Physicochemical characterization techniques include particle size analysis, zeta potential and determination of crystallinity/polymorphism. Furthermore, drug loading and drug entrapment efficiency are common parameters used to test the efficiency of SLN. Most importantly, the functionality assay of SLN is essential to predict the activity and performance in vivo. The review presented discusses the importance of SLN in drug delivery with emphasis on principles and limitations associated with their physicochemical characterization.

Original languageEnglish (US)
Pages (from-to)1565-1575
Number of pages11
JournalDrug Development and Industrial Pharmacy
Issue number12
StatePublished - Dec 1 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry


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