Placebo therapy for postmenopausal osteoporosis

Christopher Elias, Robert P. Heaney, Robert R. Recker

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Eighteen postmenopausal osteoporotic (PMO) women on placebo therapy were followed for 1 year. Serial measurements of calcium balance and kinetics, bone histomorphometry, photon absorptiometry, and radiogrammetry were obtained. Few significant changes in balance and kinetics or bone histology were seen in these women over time. Photon absorptiometry and radiogrammetry of the femoral cortex showed a significant annual bone loss however. When compared with premenopausal and healthy postmenopausal women, the annual bone loss in those with PMO was significantly greater. The ability of balance studies, photon absorptiometry, and radiogrammetry to predict the magnitude of this bone loss was similar. Finally, there was an illustration of the use of the estimated variance provided by this study for estimating sample size for future studies.

Original languageEnglish
Pages (from-to)6-13
Number of pages8
JournalCalcified Tissue International
Volume37
Issue number1
DOIs
StatePublished - Jan 1985

Fingerprint

Postmenopausal Osteoporosis
Placebos
Photon Absorptiometry
Bone and Bones
Therapeutics
Thigh
Sample Size
Histology
Calcium

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Placebo therapy for postmenopausal osteoporosis. / Elias, Christopher; Heaney, Robert P.; Recker, Robert R.

In: Calcified Tissue International, Vol. 37, No. 1, 01.1985, p. 6-13.

Research output: Contribution to journalArticle

Elias, Christopher ; Heaney, Robert P. ; Recker, Robert R. / Placebo therapy for postmenopausal osteoporosis. In: Calcified Tissue International. 1985 ; Vol. 37, No. 1. pp. 6-13.
@article{a7367b1fac0446a7a0b777566965d213,
title = "Placebo therapy for postmenopausal osteoporosis",
abstract = "Eighteen postmenopausal osteoporotic (PMO) women on placebo therapy were followed for 1 year. Serial measurements of calcium balance and kinetics, bone histomorphometry, photon absorptiometry, and radiogrammetry were obtained. Few significant changes in balance and kinetics or bone histology were seen in these women over time. Photon absorptiometry and radiogrammetry of the femoral cortex showed a significant annual bone loss however. When compared with premenopausal and healthy postmenopausal women, the annual bone loss in those with PMO was significantly greater. The ability of balance studies, photon absorptiometry, and radiogrammetry to predict the magnitude of this bone loss was similar. Finally, there was an illustration of the use of the estimated variance provided by this study for estimating sample size for future studies.",
author = "Christopher Elias and Heaney, {Robert P.} and Recker, {Robert R.}",
year = "1985",
month = "1",
doi = "10.1007/BF02557671",
language = "English",
volume = "37",
pages = "6--13",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Placebo therapy for postmenopausal osteoporosis

AU - Elias, Christopher

AU - Heaney, Robert P.

AU - Recker, Robert R.

PY - 1985/1

Y1 - 1985/1

N2 - Eighteen postmenopausal osteoporotic (PMO) women on placebo therapy were followed for 1 year. Serial measurements of calcium balance and kinetics, bone histomorphometry, photon absorptiometry, and radiogrammetry were obtained. Few significant changes in balance and kinetics or bone histology were seen in these women over time. Photon absorptiometry and radiogrammetry of the femoral cortex showed a significant annual bone loss however. When compared with premenopausal and healthy postmenopausal women, the annual bone loss in those with PMO was significantly greater. The ability of balance studies, photon absorptiometry, and radiogrammetry to predict the magnitude of this bone loss was similar. Finally, there was an illustration of the use of the estimated variance provided by this study for estimating sample size for future studies.

AB - Eighteen postmenopausal osteoporotic (PMO) women on placebo therapy were followed for 1 year. Serial measurements of calcium balance and kinetics, bone histomorphometry, photon absorptiometry, and radiogrammetry were obtained. Few significant changes in balance and kinetics or bone histology were seen in these women over time. Photon absorptiometry and radiogrammetry of the femoral cortex showed a significant annual bone loss however. When compared with premenopausal and healthy postmenopausal women, the annual bone loss in those with PMO was significantly greater. The ability of balance studies, photon absorptiometry, and radiogrammetry to predict the magnitude of this bone loss was similar. Finally, there was an illustration of the use of the estimated variance provided by this study for estimating sample size for future studies.

UR - http://www.scopus.com/inward/record.url?scp=0021954713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021954713&partnerID=8YFLogxK

U2 - 10.1007/BF02557671

DO - 10.1007/BF02557671

M3 - Article

C2 - 3922599

AN - SCOPUS:0021954713

VL - 37

SP - 6

EP - 13

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 1

ER -