Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia

Subhash Bhatia, H. H. Hsieh, K. A. Theesen, R. G. Townley, J. M. Andersen, S. Weiss, Devendra K. Agrawal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Changes in alpha-2 adrenoreceptor density and affinity during antidepressant treatment were studied using 3H-yohimbine binding to human platelet membranes. Baseline measurements were conducted in 21 patients diagnosed as having major depressive disorder with melancholia, and an equal number of age and sex matched normal controls. No differences were observed in receptor density or binding between pre-treatment subject groups and normal matched controls. Subjects participated for 6 weeks in a trial of placebo, adinazolam, or amitriptyline. Alpha-2 adrenoreceptor binding was not significantly changed from baseline following antidepressant treatment.

Original languageEnglish
Pages (from-to)47-57
Number of pages11
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume74
Issue number1
StatePublished - 1991

Fingerprint

Major Depressive Disorder
Depressive Disorder
Platelets
Antidepressive Agents
Blood Platelets
Amitriptyline
Yohimbine
Membranes
Research Design
Therapeutics
Placebos
adinazolam

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

Cite this

Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia. / Bhatia, Subhash; Hsieh, H. H.; Theesen, K. A.; Townley, R. G.; Andersen, J. M.; Weiss, S.; Agrawal, Devendra K.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 74, No. 1, 1991, p. 47-57.

Research output: Contribution to journalArticle

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