Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia

S. C. Bhatia; H. H. Hsieh; K. A. Theesen; R. G. Townley; J. M. Andersen; S. Weiss; D. K. Agrawal

Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia

S. C. Bhatia, H. H. Hsieh, K. A. Theesen, R. G. Townley, J. M. Andersen, S. Weiss, D. K. Agrawal

Research output: Contribution to journal › Article › peer-review

Abstract

Changes in alpha-2 adrenoreceptor density and affinity during antidepressant treatment were studied using ³H-yohimbine binding to human platelet membranes. Baseline measurements were conducted in 21 patients diagnosed as having major depressive disorder with melancholia, and an equal number of age and sex matched normal controls. No differences were observed in receptor density or binding between pre-treatment subject groups and normal matched controls. Subjects participated for 6 weeks in a trial of placebo, adinazolam, or amitriptyline. Alpha-2 adrenoreceptor binding was not significantly changed from baseline following antidepressant treatment.

Original language	English (US)
Pages (from-to)	47-57
Number of pages	11
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	74
Issue number	1
State	Published - Nov 7 1991

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

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Platelet alpha-2 adrenoreceptor activity pre-treatment and post-treatment in major depressive disorder with melancholia. / Bhatia, S. C.; Hsieh, H. H.; Theesen, K. A.; Townley, R. G.; Andersen, J. M.; Weiss, S.; Agrawal, D. K.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 74, No. 1, 07.11.1991, p. 47-57.

Research output: Contribution to journal › Article › peer-review

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