Pneumocystis jirovecii Pneumonia Associated with Systemic Glucocorticoids in the Treatment of Type 2 Amiodarone-Induced Thyrotoxicosis

Mark Henry Joven, Robert J. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We report a patient with type 2 amiodarone-induced thyrotoxicosis (AIT) treated with high-dose glucocorticoids who subsequently had Pneumocystis jirovecii pneumonia (PJP). Methods: Current guidelines recommend high doses of glucocorticoids for restoring euthyroidism in patients with type 2 AIT. In this case study, we discuss a potential life-threatening pitfall of high-dose glucocorticoid use in these patients. Results: A 63-year-old man with a history of paroxysmal atrial fibrillation previously treated with oral amiodarone was seen for weight loss, tremors, and fatigue. He was biochemically hyperthyroid (suppressed thyroid-stimulating hormone, elevated free thyroxine and free triiodothyronine). Oral dexamethasone was started for type 2 AIT, with dramatic improvement over 2 months. He later developed progressive shortness of breath and hypoxic respiratory failure requiring mechanical ventilation. Infectious workup revealed PJP. Despite aggressive treatment measures, he suffered numerous complications and subsequently died. He was biochemically euthyroid during his hospital stay. Conclusion: Patients with type 2 AIT treated with highdose systemic glucocorticoids are immunosuppressed and are at risk for PJP. Clinicians need to be vigilant regarding this occurrence, particularly in patients with numerous comorbidities.

Original languageEnglish (US)
Pages (from-to)e46-e49
JournalAACE Clinical Case Reports
Volume2
Issue number1
DOIs
StatePublished - Dec 1 2016

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

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