Polymorphisms in the CD14 gene associated with pulmonary function in farmers

Tricia D. LeVan, Susanna Von Essen, Debra J. Romberger, G. Patrick Lambert, Fernando D. Martinez, Monica M. Vasquez, James A. Merchant

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Rationale and Objectives: Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin. Materials and Methods: Based on our findings of increased circulating CD14 associated with the CD14/ -159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25-75) (p = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared with farmers with the A allele (n = 86). Results: No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) or CD14/-1619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299Gly and lung function or wheeze. Conclusion: We conclude that the CD14/-159 or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers.

Original languageEnglish (US)
Pages (from-to)773-779
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume171
Issue number7
DOIs
StatePublished - Apr 1 2005

Fingerprint

Lung
Genes
Alleles
Endotoxins
Genotype
Farmers
Respiratory Sounds
Airway Obstruction
Inhalation

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Polymorphisms in the CD14 gene associated with pulmonary function in farmers. / LeVan, Tricia D.; Von Essen, Susanna; Romberger, Debra J.; Lambert, G. Patrick; Martinez, Fernando D.; Vasquez, Monica M.; Merchant, James A.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 171, No. 7, 01.04.2005, p. 773-779.

Research output: Contribution to journalArticle

LeVan, Tricia D. ; Von Essen, Susanna ; Romberger, Debra J. ; Lambert, G. Patrick ; Martinez, Fernando D. ; Vasquez, Monica M. ; Merchant, James A. / Polymorphisms in the CD14 gene associated with pulmonary function in farmers. In: American Journal of Respiratory and Critical Care Medicine. 2005 ; Vol. 171, No. 7. pp. 773-779.
@article{d657f32f86224a97ace16f4c55089751,
title = "Polymorphisms in the CD14 gene associated with pulmonary function in farmers",
abstract = "Rationale and Objectives: Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin. Materials and Methods: Based on our findings of increased circulating CD14 associated with the CD14/ -159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25-75) (p = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared with farmers with the A allele (n = 86). Results: No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) or CD14/-1619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299Gly and lung function or wheeze. Conclusion: We conclude that the CD14/-159 or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers.",
author = "LeVan, {Tricia D.} and {Von Essen}, Susanna and Romberger, {Debra J.} and Lambert, {G. Patrick} and Martinez, {Fernando D.} and Vasquez, {Monica M.} and Merchant, {James A.}",
year = "2005",
month = "4",
day = "1",
doi = "10.1164/rccm.200404-530OC",
language = "English (US)",
volume = "171",
pages = "773--779",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "7",

}

TY - JOUR

T1 - Polymorphisms in the CD14 gene associated with pulmonary function in farmers

AU - LeVan, Tricia D.

AU - Von Essen, Susanna

AU - Romberger, Debra J.

AU - Lambert, G. Patrick

AU - Martinez, Fernando D.

AU - Vasquez, Monica M.

AU - Merchant, James A.

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Rationale and Objectives: Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin. Materials and Methods: Based on our findings of increased circulating CD14 associated with the CD14/ -159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25-75) (p = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared with farmers with the A allele (n = 86). Results: No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) or CD14/-1619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299Gly and lung function or wheeze. Conclusion: We conclude that the CD14/-159 or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers.

AB - Rationale and Objectives: Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin. Materials and Methods: Based on our findings of increased circulating CD14 associated with the CD14/ -159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin-exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and mean forced expiratory flow during the middle half of the FVC (FEF25-75) (p = 0.05) compared with farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared with farmers with the A allele (n = 86). Results: No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) or CD14/-1619G (p = 0.019) compared with farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299Gly and lung function or wheeze. Conclusion: We conclude that the CD14/-159 or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers.

UR - http://www.scopus.com/inward/record.url?scp=16344368102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16344368102&partnerID=8YFLogxK

U2 - 10.1164/rccm.200404-530OC

DO - 10.1164/rccm.200404-530OC

M3 - Article

C2 - 15591473

AN - SCOPUS:16344368102

VL - 171

SP - 773

EP - 779

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 7

ER -