Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study

Yan Fang Guo, Dong Hai Xiong, Hui Shen, Lan Juan Zhao, Peng Xiao, Yan Guo, Wei Wang, Tie Lin Yang, Robert R. Recker, Hong Wen Deng

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Abstract

Background: The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes. Participants and methods: To investigate the association between LRP5 polymorphisms and obesity, 27 single-nucleotide polymorphisms (SNPs), spacing about 5 kb apart on average and covering the full transcript length of the LRP5 gene, were genotyped in 1873 Caucasian people from 405 nuclear families. Obesity (defined as body mass index (BMI) >30 kg/m2) and three obesity-related phenotypes (BMI, fat mass and percentage of fat mass (PFM)) were investigated. Results: Single markers (12 tagging SNPs and 4 untaggable SNPs) and haplotypes (5 blocks) were tested for associations, using family-based designs. SNP4 (rs4988300) and SNP6 (rs634008) located in block 2 (intron 1) showed significant associations with obesity and BMI after Bonferroni correction (SNP4: p

Original languageEnglish
Pages (from-to)798-803
Number of pages6
JournalJournal of Medical Genetics
Volume43
Issue number10
DOIs
Publication statusPublished - Oct 2006

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All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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