Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study

Yan Fang Guo, Dong Hai Xiong, Hui Shen, Lan Juan Zhao, Peng Xiao, Yan Guo, Wei Wang, Tie Lin Yang, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

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Abstract

Background: The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes. Participants and methods: To investigate the association between LRP5 polymorphisms and obesity, 27 single-nucleotide polymorphisms (SNPs), spacing about 5 kb apart on average and covering the full transcript length of the LRP5 gene, were genotyped in 1873 Caucasian people from 405 nuclear families. Obesity (defined as body mass index (BMI) >30 kg/m2) and three obesity-related phenotypes (BMI, fat mass and percentage of fat mass (PFM)) were investigated. Results: Single markers (12 tagging SNPs and 4 untaggable SNPs) and haplotypes (5 blocks) were tested for associations, using family-based designs. SNP4 (rs4988300) and SNP6 (rs634008) located in block 2 (intron 1) showed significant associations with obesity and BMI after Bonferroni correction (SNP4: p

Original languageEnglish
Pages (from-to)798-803
Number of pages6
JournalJournal of Medical Genetics
Volume43
Issue number10
DOIs
StatePublished - Oct 2006

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Low Density Lipoprotein Receptor-Related Protein-5
Obesity
Phenotype
Single Nucleotide Polymorphism
Body Mass Index
Genes
Fats
Essential Genes
Nuclear Family
Introns
Haplotypes
Cholesterol
Glucose

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study. / Guo, Yan Fang; Xiong, Dong Hai; Shen, Hui; Zhao, Lan Juan; Xiao, Peng; Guo, Yan; Wang, Wei; Yang, Tie Lin; Recker, Robert R.; Deng, Hong Wen.

In: Journal of Medical Genetics, Vol. 43, No. 10, 10.2006, p. 798-803.

Research output: Contribution to journalArticle

Guo, Yan Fang ; Xiong, Dong Hai ; Shen, Hui ; Zhao, Lan Juan ; Xiao, Peng ; Guo, Yan ; Wang, Wei ; Yang, Tie Lin ; Recker, Robert R. ; Deng, Hong Wen. / Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study. In: Journal of Medical Genetics. 2006 ; Vol. 43, No. 10. pp. 798-803.
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AU - Guo, Yan Fang

AU - Xiong, Dong Hai

AU - Shen, Hui

AU - Zhao, Lan Juan

AU - Xiao, Peng

AU - Guo, Yan

AU - Wang, Wei

AU - Yang, Tie Lin

AU - Recker, Robert R.

AU - Deng, Hong Wen

PY - 2006/10

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N2 - Background: The low-density lipoprotein receptor-related protein 5 (LRP5) gene, essential for glucose and cholesterol metabolism, may have a role in the aetiology of obesity, an important risk factor for diabetes. Participants and methods: To investigate the association between LRP5 polymorphisms and obesity, 27 single-nucleotide polymorphisms (SNPs), spacing about 5 kb apart on average and covering the full transcript length of the LRP5 gene, were genotyped in 1873 Caucasian people from 405 nuclear families. Obesity (defined as body mass index (BMI) >30 kg/m2) and three obesity-related phenotypes (BMI, fat mass and percentage of fat mass (PFM)) were investigated. Results: Single markers (12 tagging SNPs and 4 untaggable SNPs) and haplotypes (5 blocks) were tested for associations, using family-based designs. SNP4 (rs4988300) and SNP6 (rs634008) located in block 2 (intron 1) showed significant associations with obesity and BMI after Bonferroni correction (SNP4: p

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