Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females

Volodymyr Dvornyk, Ji Rong Long, Peng Yuan Liu, Hui Shen, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We tested association of four single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene (VDR) with age at surgical and natural menopause in a sample of Caucasians composed of 153 women with surgical and 260 with natural menopause. A significant association was observed between age at surgical menopause and two SNPs, rs1544410 (BsmI) and rs731236 (TaqI) (p <0.05). For rs1544410, homozygotes of the minor allele, AA, had about two-fold higher risk of surgical menopause than homozygotes of the major allele, GG (95% confidence ratio (CI) 1.09-3.82). For rs731236, the CC subjects had a greater chance of surgical menopause than the TT subjects (odds ratio = 2.01, 95% CI 1.07-3.78). Since rs1544410 and rs731236 are in strong linkage disequilibrium, the haplotypes based on these two loci were also tested. The haplotype AC was highly significantly associated with age at surgical menopause (p = 0.008). Women with this haplotype had surgical menopause on average 2.8 years earlier than non-carriers. These results reveal the potential effect of the VDR gene on ovaries and uterus, and suggest that its SNPs can be used as predictors of genetic susceptibility for early surgical menopause and respective causal health problems.

Original languageEnglish
Pages (from-to)552-556
Number of pages5
JournalGynecological Endocrinology
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2006

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Calcitriol Receptors
Menopause
Genes
Haplotypes
Single Nucleotide Polymorphism
Homozygote
Alleles
Linkage Disequilibrium
Genetic Predisposition to Disease
Uterus
Ovary
Odds Ratio
Health

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Obstetrics and Gynecology

Cite this

Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females. / Dvornyk, Volodymyr; Long, Ji Rong; Liu, Peng Yuan; Shen, Hui; Recker, Robert R.; Deng, Hong Wen.

In: Gynecological Endocrinology, Vol. 22, No. 10, 01.10.2006, p. 552-556.

Research output: Contribution to journalArticle

Dvornyk, Volodymyr ; Long, Ji Rong ; Liu, Peng Yuan ; Shen, Hui ; Recker, Robert R. ; Deng, Hong Wen. / Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females. In: Gynecological Endocrinology. 2006 ; Vol. 22, No. 10. pp. 552-556.
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