Polyploidy can drive rapid adaptation in yeast

Anna Selmecki, Yosef E. Maruvka, Phillip A. Richmond, Marie Guillet, Noam Shoresh, Amber L. Sorenson, Subhajyoti De, Roy Kishony, Franziska Michor, Robin Dowell, David Pellman

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Polyploidy is observed across the tree of life, yet its influence on evolution remains incompletely understood. Polyploidy, usually whole-genome duplication, is proposed to alter the rate of evolutionary adaptation. This could occur through complex effects on the frequency or fitness of beneficial mutations. For example, in diverse cell types and organisms, immediately after a whole-genome duplication, newly formed polyploids missegregate chromosomes and undergo genetic instability. The instability following whole-genome duplications is thought to provide adaptive mutations in microorganisms and can promote tumorigenesis in mammalian cells. Polyploidy may also affect adaptation independently of beneficial mutations through ploidy-specific changes in cell physiology. Here we perform in vitro evolution experiments to test directly whether polyploidy can accelerate evolutionary adaptation. Compared with haploids and diploids, tetraploids undergo significantly faster adaptation. Mathematical modelling suggests that rapid adaptation of tetraploids is driven by higher rates of beneficial mutations with stronger fitness effects, which is supported by whole-genome sequencing and phenotypic analyses of evolved clones. Chromosome aneuploidy, concerted chromosome loss, and point mutations all provide large fitness gains. We identify several mutations whose beneficial effects are manifest specifically in the tetraploid strains. Together, these results provide direct quantitative evidence that in some environments polyploidy can accelerate evolutionary adaptation.

Original languageEnglish
Pages (from-to)349-351
Number of pages3
JournalNature
Volume519
Issue number7543
DOIs
StatePublished - Mar 19 2015

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Polyploidy
Yeasts
Tetraploidy
Genome
Mutation
Chromosomes
Cell Physiological Phenomena
Ploidies
Haploidy
Aneuploidy
Mutation Rate
Diploidy
Point Mutation
Carcinogenesis
Clone Cells

All Science Journal Classification (ASJC) codes

  • General

Cite this

Selmecki, A., Maruvka, Y. E., Richmond, P. A., Guillet, M., Shoresh, N., Sorenson, A. L., ... Pellman, D. (2015). Polyploidy can drive rapid adaptation in yeast. Nature, 519(7543), 349-351. https://doi.org/10.1038/nature14187

Polyploidy can drive rapid adaptation in yeast. / Selmecki, Anna; Maruvka, Yosef E.; Richmond, Phillip A.; Guillet, Marie; Shoresh, Noam; Sorenson, Amber L.; De, Subhajyoti; Kishony, Roy; Michor, Franziska; Dowell, Robin; Pellman, David.

In: Nature, Vol. 519, No. 7543, 19.03.2015, p. 349-351.

Research output: Contribution to journalArticle

Selmecki, A, Maruvka, YE, Richmond, PA, Guillet, M, Shoresh, N, Sorenson, AL, De, S, Kishony, R, Michor, F, Dowell, R & Pellman, D 2015, 'Polyploidy can drive rapid adaptation in yeast', Nature, vol. 519, no. 7543, pp. 349-351. https://doi.org/10.1038/nature14187
Selmecki A, Maruvka YE, Richmond PA, Guillet M, Shoresh N, Sorenson AL et al. Polyploidy can drive rapid adaptation in yeast. Nature. 2015 Mar 19;519(7543):349-351. https://doi.org/10.1038/nature14187
Selmecki, Anna ; Maruvka, Yosef E. ; Richmond, Phillip A. ; Guillet, Marie ; Shoresh, Noam ; Sorenson, Amber L. ; De, Subhajyoti ; Kishony, Roy ; Michor, Franziska ; Dowell, Robin ; Pellman, David. / Polyploidy can drive rapid adaptation in yeast. In: Nature. 2015 ; Vol. 519, No. 7543. pp. 349-351.
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