Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases

Importance of community isolates with blaCTX-M genes

Johann D D Pitout, Nancy D. Hanson, Deirdre L. Church, Kevin B. Laupland

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

A prospective, population-based laboratory surveillance study was conducted to define the epidemiology of extended-spectrum β-lactamase-producing Escherichia coli infections in the Calgary Health Region during the years 2000-2002. The incidence was 5.5 cases per 100,000 population per year. The annualized incidence of 3.9 cases per 100,000 population for January through March was significantly lower than the incidence for the other quarters of the year (6.0 per 100,000 population; PCTX-M genes from the CTX-M-I subgroup and 87 (55%) from the CTX-M-III subgroup. Ciprofloxacin resistance was independently associated with CTX-M-β-lactamases (odds ratio, 14.2; 95% confidence interval, 3.69-54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk.

Original languageEnglish
Pages (from-to)1736-1741
Number of pages6
JournalClinical Infectious Diseases
Volume38
Issue number12
DOIs
StatePublished - Jun 15 2004

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Escherichia coli
Population
Genes
Incidence
Escherichia coli Infections
Ciprofloxacin
Epidemiology
Odds Ratio
Confidence Intervals
Health
Infection

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases : Importance of community isolates with blaCTX-M genes. / Pitout, Johann D D; Hanson, Nancy D.; Church, Deirdre L.; Laupland, Kevin B.

In: Clinical Infectious Diseases, Vol. 38, No. 12, 15.06.2004, p. 1736-1741.

Research output: Contribution to journalArticle

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