Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases: Importance of community isolates with blaCTX-M genes

Johann D.D. Pitout; Nancy D. Hanson; Deirdre L. Church; Kevin B. Laupland

doi:10.1086/421094

Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases: Importance of community isolates with bla_CTX-M genes

Johann D.D. Pitout, Nancy D. Hanson, Deirdre L. Church, Kevin B. Laupland

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

A prospective, population-based laboratory surveillance study was conducted to define the epidemiology of extended-spectrum β-lactamase-producing Escherichia coli infections in the Calgary Health Region during the years 2000-2002. The incidence was 5.5 cases per 100,000 population per year. The annualized incidence of 3.9 cases per 100,000 population for January through March was significantly lower than the incidence for the other quarters of the year (6.0 per 100,000 population; PCTX-M genes from the CTX-M-I subgroup and 87 (55%) from the CTX-M-III subgroup. Ciprofloxacin resistance was independently associated with CTX-M-β-lactamases (odds ratio, 14.2; 95% confidence interval, 3.69-54.84). Strains of E. coli with bla_CTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk.

Original language	English (US)
Pages (from-to)	1736-1741
Number of pages	6
Journal	Clinical Infectious Diseases
Volume	38
Issue number	12
DOIs	https://doi.org/10.1086/421094
State	Published - Jun 15 2004

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Access to Document

10.1086/421094

Cite this

Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases : Importance of community isolates with bla_CTX-M genes. / Pitout, Johann D.D.; Hanson, Nancy D.; Church, Deirdre L.; Laupland, Kevin B.

In: Clinical Infectious Diseases, Vol. 38, No. 12, 15.06.2004, p. 1736-1741.

Research output: Contribution to journal › Article › peer-review

@article{7f8402e346b3434ba041562a351ffd57,

title = "Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases: Importance of community isolates with blaCTX-M genes",

abstract = "A prospective, population-based laboratory surveillance study was conducted to define the epidemiology of extended-spectrum β-lactamase-producing Escherichia coli infections in the Calgary Health Region during the years 2000-2002. The incidence was 5.5 cases per 100,000 population per year. The annualized incidence of 3.9 cases per 100,000 population for January through March was significantly lower than the incidence for the other quarters of the year (6.0 per 100,000 population; PCTX-M genes from the CTX-M-I subgroup and 87 (55%) from the CTX-M-III subgroup. Ciprofloxacin resistance was independently associated with CTX-M-β-lactamases (odds ratio, 14.2; 95% confidence interval, 3.69-54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk.",

author = "Pitout, {Johann D.D.} and Hanson, {Nancy D.} and Church, {Deirdre L.} and Laupland, {Kevin B.}",

note = "Funding Information: Financial support. University of Calgary Dean{\textquoteright}s Starter Grant (grant 75-4777). Funding Information: Conflict of interest. K.B.L. received research funding from AstraZeneca and Bristol Myers Squibb for previous unrelated studies. None of the authors had professional or financial conflicts of interest that would influence the conduct or reporting of this study.",

year = "2004",

month = jun,

day = "15",

doi = "10.1086/421094",

language = "English (US)",

volume = "38",

pages = "1736--1741",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases

T2 - Importance of community isolates with blaCTX-M genes

AU - Pitout, Johann D.D.

AU - Hanson, Nancy D.

AU - Church, Deirdre L.

AU - Laupland, Kevin B.

N1 - Funding Information: Financial support. University of Calgary Dean’s Starter Grant (grant 75-4777). Funding Information: Conflict of interest. K.B.L. received research funding from AstraZeneca and Bristol Myers Squibb for previous unrelated studies. None of the authors had professional or financial conflicts of interest that would influence the conduct or reporting of this study.

PY - 2004/6/15

Y1 - 2004/6/15

N2 - A prospective, population-based laboratory surveillance study was conducted to define the epidemiology of extended-spectrum β-lactamase-producing Escherichia coli infections in the Calgary Health Region during the years 2000-2002. The incidence was 5.5 cases per 100,000 population per year. The annualized incidence of 3.9 cases per 100,000 population for January through March was significantly lower than the incidence for the other quarters of the year (6.0 per 100,000 population; PCTX-M genes from the CTX-M-I subgroup and 87 (55%) from the CTX-M-III subgroup. Ciprofloxacin resistance was independently associated with CTX-M-β-lactamases (odds ratio, 14.2; 95% confidence interval, 3.69-54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk.

AB - A prospective, population-based laboratory surveillance study was conducted to define the epidemiology of extended-spectrum β-lactamase-producing Escherichia coli infections in the Calgary Health Region during the years 2000-2002. The incidence was 5.5 cases per 100,000 population per year. The annualized incidence of 3.9 cases per 100,000 population for January through March was significantly lower than the incidence for the other quarters of the year (6.0 per 100,000 population; PCTX-M genes from the CTX-M-I subgroup and 87 (55%) from the CTX-M-III subgroup. Ciprofloxacin resistance was independently associated with CTX-M-β-lactamases (odds ratio, 14.2; 95% confidence interval, 3.69-54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk.

UR - http://www.scopus.com/inward/record.url?scp=2942639503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942639503&partnerID=8YFLogxK

U2 - 10.1086/421094

DO - 10.1086/421094

M3 - Article

C2 - 15227620

AN - SCOPUS:2942639503

VL - 38

SP - 1736

EP - 1741

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 12

ER -

Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum β-Lactamases: Importance of community isolates with bla_CTX-M genes

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this