Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients

Christian Frisch, Joachim Hanke, Sven Kleinerüschkamp, Sandra Röske, Sabine Kaaden, Christian E. Elger, Johannes Schramm, Denis M. Yilmazer-Hanke, Christoph Helmstaedter

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Neuropeptide Y (NPY) has been implicated in depression, anxiety, and memory. Expression of human NPY and the number of NPY-positive neurons in the rodent amygdala correlate with anxiety and stress-related behavior. Increased NPY expression in the epileptic brain is supposed to represent an adaptive mechanism counteracting epilepsy-related hyperexcitability. We attempted to investigate whether NPY-positive neurons in the human amygdala are involved in these processes. Methods: In 34 adult epileptic patients undergoing temporal lobe surgery for seizure control, the density of NPY-positive neurons was assessed in the basal, lateral, and accessory-basal amygdala nuclei. Cell counts were related to self-reported depression, anxiety, quality of life, clinical parameters (onset and duration of epilepsy, seizure frequency), antiepileptic medication, and amygdala and hippocampal magnetic resonance imaging volumetric measures. Results: Densities of NPY-positive basolateral amygdala neurons showed significant positive correlations with depression and anxiety scores, and they were negatively correlated with lamotrigine dosage. In contrast, NPY cell counts showed no relation to clinical factors or amygdalar and hippocampal volumes. Conclusions: The results point to a role of amygdalar NPY in negative emotion and might reflect state processes at least in patients with temporal lobe epilepsy. Correlations with common clinical parameters of epilepsy were not found. The question of a disease-related reduction of the density of NPY-positive amygdalar neurons in temporal lobe epilepsy requires further investigation.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalBiological Psychiatry
Volume66
Issue number5
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

Fingerprint

Neuropeptide Y
Amygdala
Epilepsy
Anxiety
Depression
Neurons
Temporal Lobe Epilepsy
Seizures
Cell Count
Temporal Lobe
Anticonvulsants
Rodentia
Emotions
Quality of Life
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

Cite this

Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients. / Frisch, Christian; Hanke, Joachim; Kleinerüschkamp, Sven; Röske, Sandra; Kaaden, Sabine; Elger, Christian E.; Schramm, Johannes; Yilmazer-Hanke, Denis M.; Helmstaedter, Christoph.

In: Biological Psychiatry, Vol. 66, No. 5, 01.09.2009, p. 433-440.

Research output: Contribution to journalArticle

Frisch, Christian ; Hanke, Joachim ; Kleinerüschkamp, Sven ; Röske, Sandra ; Kaaden, Sabine ; Elger, Christian E. ; Schramm, Johannes ; Yilmazer-Hanke, Denis M. ; Helmstaedter, Christoph. / Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients. In: Biological Psychiatry. 2009 ; Vol. 66, No. 5. pp. 433-440.
@article{08efc439e8a54fed95c4aa3e6cf8cf69,
title = "Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients",
abstract = "Background: Neuropeptide Y (NPY) has been implicated in depression, anxiety, and memory. Expression of human NPY and the number of NPY-positive neurons in the rodent amygdala correlate with anxiety and stress-related behavior. Increased NPY expression in the epileptic brain is supposed to represent an adaptive mechanism counteracting epilepsy-related hyperexcitability. We attempted to investigate whether NPY-positive neurons in the human amygdala are involved in these processes. Methods: In 34 adult epileptic patients undergoing temporal lobe surgery for seizure control, the density of NPY-positive neurons was assessed in the basal, lateral, and accessory-basal amygdala nuclei. Cell counts were related to self-reported depression, anxiety, quality of life, clinical parameters (onset and duration of epilepsy, seizure frequency), antiepileptic medication, and amygdala and hippocampal magnetic resonance imaging volumetric measures. Results: Densities of NPY-positive basolateral amygdala neurons showed significant positive correlations with depression and anxiety scores, and they were negatively correlated with lamotrigine dosage. In contrast, NPY cell counts showed no relation to clinical factors or amygdalar and hippocampal volumes. Conclusions: The results point to a role of amygdalar NPY in negative emotion and might reflect state processes at least in patients with temporal lobe epilepsy. Correlations with common clinical parameters of epilepsy were not found. The question of a disease-related reduction of the density of NPY-positive amygdalar neurons in temporal lobe epilepsy requires further investigation.",
author = "Christian Frisch and Joachim Hanke and Sven Kleiner{\"u}schkamp and Sandra R{\"o}ske and Sabine Kaaden and Elger, {Christian E.} and Johannes Schramm and Yilmazer-Hanke, {Denis M.} and Christoph Helmstaedter",
year = "2009",
month = "9",
day = "1",
doi = "10.1016/j.biopsych.2009.03.025",
language = "English",
volume = "66",
pages = "433--440",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients

AU - Frisch, Christian

AU - Hanke, Joachim

AU - Kleinerüschkamp, Sven

AU - Röske, Sandra

AU - Kaaden, Sabine

AU - Elger, Christian E.

AU - Schramm, Johannes

AU - Yilmazer-Hanke, Denis M.

AU - Helmstaedter, Christoph

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Background: Neuropeptide Y (NPY) has been implicated in depression, anxiety, and memory. Expression of human NPY and the number of NPY-positive neurons in the rodent amygdala correlate with anxiety and stress-related behavior. Increased NPY expression in the epileptic brain is supposed to represent an adaptive mechanism counteracting epilepsy-related hyperexcitability. We attempted to investigate whether NPY-positive neurons in the human amygdala are involved in these processes. Methods: In 34 adult epileptic patients undergoing temporal lobe surgery for seizure control, the density of NPY-positive neurons was assessed in the basal, lateral, and accessory-basal amygdala nuclei. Cell counts were related to self-reported depression, anxiety, quality of life, clinical parameters (onset and duration of epilepsy, seizure frequency), antiepileptic medication, and amygdala and hippocampal magnetic resonance imaging volumetric measures. Results: Densities of NPY-positive basolateral amygdala neurons showed significant positive correlations with depression and anxiety scores, and they were negatively correlated with lamotrigine dosage. In contrast, NPY cell counts showed no relation to clinical factors or amygdalar and hippocampal volumes. Conclusions: The results point to a role of amygdalar NPY in negative emotion and might reflect state processes at least in patients with temporal lobe epilepsy. Correlations with common clinical parameters of epilepsy were not found. The question of a disease-related reduction of the density of NPY-positive amygdalar neurons in temporal lobe epilepsy requires further investigation.

AB - Background: Neuropeptide Y (NPY) has been implicated in depression, anxiety, and memory. Expression of human NPY and the number of NPY-positive neurons in the rodent amygdala correlate with anxiety and stress-related behavior. Increased NPY expression in the epileptic brain is supposed to represent an adaptive mechanism counteracting epilepsy-related hyperexcitability. We attempted to investigate whether NPY-positive neurons in the human amygdala are involved in these processes. Methods: In 34 adult epileptic patients undergoing temporal lobe surgery for seizure control, the density of NPY-positive neurons was assessed in the basal, lateral, and accessory-basal amygdala nuclei. Cell counts were related to self-reported depression, anxiety, quality of life, clinical parameters (onset and duration of epilepsy, seizure frequency), antiepileptic medication, and amygdala and hippocampal magnetic resonance imaging volumetric measures. Results: Densities of NPY-positive basolateral amygdala neurons showed significant positive correlations with depression and anxiety scores, and they were negatively correlated with lamotrigine dosage. In contrast, NPY cell counts showed no relation to clinical factors or amygdalar and hippocampal volumes. Conclusions: The results point to a role of amygdalar NPY in negative emotion and might reflect state processes at least in patients with temporal lobe epilepsy. Correlations with common clinical parameters of epilepsy were not found. The question of a disease-related reduction of the density of NPY-positive amygdalar neurons in temporal lobe epilepsy requires further investigation.

UR - http://www.scopus.com/inward/record.url?scp=68049139263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68049139263&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2009.03.025

DO - 10.1016/j.biopsych.2009.03.025

M3 - Article

VL - 66

SP - 433

EP - 440

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 5

ER -