Potential interactions between exercise and drug therapy

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Certain physiological changes caused by aerobic exercise can alter the pharmacokinetics of some drugs. A systematic review of the pharmacokinetic changes that can affect drugs as a result of aerobic exercise is provided. Eleven commonly used drugs are reviewed for their potential interaction with exercising patients. Serum concentrations of two β-blocking agents, atenolol and propranolol, and one antibiotic, doxycycline, have shown to increase as a result of exercise. No pharmacokinetic changes have been found in exercising patients taking carvedilol or verapamil. Patients who exercise after taking digoxin experience a decreased digoxin serum concentration with an increased skeletal muscle concentration. The clearance of theophylline has been shown to decrease resulting in an increase in plasma half-life during exercise. The risk of hypoglycaemia may increase when patients with diabetes mellitus inject insulin into a muscle just prior to exercising that muscle. Increasing physical activity in patients taking warfarin has been shown to decrease the international normalised ratio. Much is still unknown regarding the interactions that exist between exercise and drug therapy. More studies need to be completed in this area before definite conclusions are made and clinical relevance can be established. Clinicians should be aware that the potential for such interactions exists, especially for drugs with a narrow therapeutic range and in patients who participate in extreme sporting activities.

Original languageEnglish
Pages (from-to)293-306
Number of pages14
JournalSports Medicine
Volume34
Issue number5
DOIs
StatePublished - 2004

Fingerprint

Exercise Therapy
Exercise
Drug Therapy
Pharmacokinetics
Digoxin
Pharmaceutical Preparations
Muscles
Atenolol
International Normalized Ratio
Doxycycline
Warfarin
Theophylline
Verapamil
Serum
Hypoglycemia
Propranolol
Half-Life
Diabetes Mellitus
Skeletal Muscle
Insulin

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Potential interactions between exercise and drug therapy. / Lenz, Thomas L.; Lenz, Nancy J.; Faulkner, Michele A.

In: Sports Medicine, Vol. 34, No. 5, 2004, p. 293-306.

Research output: Contribution to journalReview article

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