Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients. Results of a prospective study

Gurjit S. Mandair, Francis W L Esmonde-White, Mohammed P. Akhter, Aaron M. Swift, Jaclynn Kreider, Steven A. Goldstein, Robert R. Recker, Michael D. Morris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

As part of our ongoing assessment of bone tissue composition and structure, we report the first experimental protocols of a prospective study to investigate the potential of using Raman spectroscopy to diagnose and predict skeletal fragility in postmenopausal osteoporosis patients. This multi-center study will assess several potential spectroscopic and X-ray based diagnostic techniques. One hundred and twenty participants will be enrolled in this five year study and the investigators will be blinded to information concerning patient history and status. Iliac crest bone biopsy specimens are provided with no identifying information except a patient study number. Our team will use micro-computed tomography (micro-CT) to identify regions of interest in both cortical and cancellous bone from specimens delivered to us. Raman mapping will be performed using a line-focused 785 nm laser in order to obtain local and averaged values on several spectroscopic metrics of bone quality. These metrics include carbonate/phosphate and phosphate/matrix ratios. Results from an initial set of biopsies will be presented. Protocols for obtaining measurements are discussed, with emphasis on the challenges presented by the use of fixed and polymer embedded specimens. These protocols are illustrated will data from a biopsy specimen.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics VI
Volume7548
DOIs
StatePublished - 2010
EventPhotonic Therapeutics and Diagnostics VI - San Francisco, CA, United States
Duration: Jan 23 2010Jan 25 2010

Other

OtherPhotonic Therapeutics and Diagnostics VI
CountryUnited States
CitySan Francisco, CA
Period1/23/101/25/10

Fingerprint

osteoporosis
Raman Spectrum Analysis
bones
Osteoporosis
Raman spectroscopy
Biopsy
Bone
Prospective Studies
Bone and Bones
evaluation
Phosphates
phosphates
Postmenopausal Osteoporosis
Carbonates
Radiography
Polymers
Lasers
Tomography
Research Personnel
carbonates

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Mandair, G. S., Esmonde-White, F. W. L., Akhter, M. P., Swift, A. M., Kreider, J., Goldstein, S. A., ... Morris, M. D. (2010). Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients. Results of a prospective study. In Photonic Therapeutics and Diagnostics VI (Vol. 7548). [754846] https://doi.org/10.1117/12.842515

Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients. Results of a prospective study. / Mandair, Gurjit S.; Esmonde-White, Francis W L; Akhter, Mohammed P.; Swift, Aaron M.; Kreider, Jaclynn; Goldstein, Steven A.; Recker, Robert R.; Morris, Michael D.

Photonic Therapeutics and Diagnostics VI. Vol. 7548 2010. 754846.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mandair, GS, Esmonde-White, FWL, Akhter, MP, Swift, AM, Kreider, J, Goldstein, SA, Recker, RR & Morris, MD 2010, Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients. Results of a prospective study. in Photonic Therapeutics and Diagnostics VI. vol. 7548, 754846, Photonic Therapeutics and Diagnostics VI, San Francisco, CA, United States, 1/23/10. https://doi.org/10.1117/12.842515
Mandair GS, Esmonde-White FWL, Akhter MP, Swift AM, Kreider J, Goldstein SA et al. Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients. Results of a prospective study. In Photonic Therapeutics and Diagnostics VI. Vol. 7548. 2010. 754846 https://doi.org/10.1117/12.842515
Mandair, Gurjit S. ; Esmonde-White, Francis W L ; Akhter, Mohammed P. ; Swift, Aaron M. ; Kreider, Jaclynn ; Goldstein, Steven A. ; Recker, Robert R. ; Morris, Michael D. / Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients. Results of a prospective study. Photonic Therapeutics and Diagnostics VI. Vol. 7548 2010.
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