Potential role of prolactin in antipsychotic-mediated association of schizophrenia and type 2 diabetes

Brandon Oberweis, Claudia Gragnoli

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

It remains unclear why atypical antipsychotics confer a risk for hyperglycemia compared to typical antipsychotics. Atypical antipsychotics antagonize dopamine receptors-2 (D2) and serotonin (5-HT) receptors-2, while typical antipsychotics antagonize only D2 receptors. We aimed at elucidating the mechanistic differences between the role of typical and atypical antipsychotics on prolactin levels and glucose regulation. A Medline search was conducted during 2010 using the search terms type 2 diabetes (T2D), typical/atypical antipsychotics, schizophrenia, prolactin, and serotonin. We discuss the effect of typical and atypical antipsychotics on prolactin levels and glucose regulation. Given that prolactin is under negative control by dopamine and positive control by serotonin, typical antipsychotics induce elevations in prolactin, while atypical antipsychotics do not. Research studies show protective effects of prolactin on T2D. We hypothesize that the difference in induction of T2D between typical and atypical antipsychotics is due to the antipsychotic receptor binding mediated effect in changes in prolactin levels.

Original languageEnglish (US)
Pages (from-to)3001-3006
Number of pages6
JournalJournal of Cellular Physiology
Volume227
Issue number8
DOIs
StatePublished - Aug 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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